Bancroftian filariasis: long-term effect of the DEC provocative day test on microfilaraemia

Poul Erik Simonsen; Dan Wolf Meyrowitsch; W.H. Makunde

doi:10.1016/S0035-9203(97)90079-1

Bancroftian filariasis: long-term effect of the DEC provocative day test on microfilaraemia

Poul Erik Simonsen, Dan Wolf Meyrowitsch, W.H. Makunde

9 Citations (Scopus)

Abstract

The diethylcarbamazine (DEC) provocative day test has been widely used for daytime diagnosis of Wuchereria bancrofti infections in areas where microfilariae exhibit nocturnal periodicity. Since DEC is also the primary drug for treatment of bancroftian filariasis, we examined the long term effect of the test on microfilaraemia in 2 groups of individuals receiving either 100 mg of DEC (n = 51) or placebo (n = 20). The low dose of DEC had a significant therapeutic effect. One year after treatment, the geometric mean intensity of microfilaraemia was reduced by 86·1%, and 10·6% of the individuals were amicrofilaraemic. No significant reduction of microfilaraemia was observed in the placebo group. The results imply that the DEC provocative day test should not be used as a diagnostic tool in follow-up studies on microfilaraemias.

Original language	English
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	91
Issue number	3
Pages (from-to)	290-293
ISSN	0035-9203
DOIs	https://doi.org/10.1016/S0035-9203(97)90079-1
Publication status	Published - 1997

Access to Document

10.1016/S0035-9203(97)90079-1

Cite this

@article{a6160b8074ca11dbbee902004c4f4f50,

title = "Bancroftian filariasis: long-term effect of the DEC provocative day test on microfilaraemia",

abstract = "The diethylcarbamazine (DEC) provocative day test has been widely used for daytime diagnosis of Wuchereria bancrofti infections in areas where microfilariae exhibit nocturnal periodicity. Since DEC is also the primary drug for treatment of bancroftian filariasis, we examined the long term effect of the test on microfilaraemia in 2 groups of individuals receiving either 100 mg of DEC (n = 51) or placebo (n = 20). The low dose of DEC had a significant therapeutic effect. One year after treatment, the geometric mean intensity of microfilaraemia was reduced by 86·1%, and 10·6% of the individuals were amicrofilaraemic. No significant reduction of microfilaraemia was observed in the placebo group. The results imply that the DEC provocative day test should not be used as a diagnostic tool in follow-up studies on microfilaraemias.",

author = "Simonsen, {Poul Erik} and Meyrowitsch, {Dan Wolf} and W.H. Makunde",

note = "Author Keywords: Author Keywords: filariasis; Wuchereria bancrofti; diagnosis; diethylcarbamazine; provocative day test",

year = "1997",

doi = "10.1016/S0035-9203(97)90079-1",

language = "English",

volume = "91",

pages = "290--293",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

issn = "0035-9203",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Bancroftian filariasis: long-term effect of the DEC provocative day test on microfilaraemia

AU - Simonsen, Poul Erik

AU - Meyrowitsch, Dan Wolf

AU - Makunde, W.H.

N1 - Author Keywords: Author Keywords: filariasis; Wuchereria bancrofti; diagnosis; diethylcarbamazine; provocative day test

PY - 1997

Y1 - 1997

N2 - The diethylcarbamazine (DEC) provocative day test has been widely used for daytime diagnosis of Wuchereria bancrofti infections in areas where microfilariae exhibit nocturnal periodicity. Since DEC is also the primary drug for treatment of bancroftian filariasis, we examined the long term effect of the test on microfilaraemia in 2 groups of individuals receiving either 100 mg of DEC (n = 51) or placebo (n = 20). The low dose of DEC had a significant therapeutic effect. One year after treatment, the geometric mean intensity of microfilaraemia was reduced by 86·1%, and 10·6% of the individuals were amicrofilaraemic. No significant reduction of microfilaraemia was observed in the placebo group. The results imply that the DEC provocative day test should not be used as a diagnostic tool in follow-up studies on microfilaraemias.

AB - The diethylcarbamazine (DEC) provocative day test has been widely used for daytime diagnosis of Wuchereria bancrofti infections in areas where microfilariae exhibit nocturnal periodicity. Since DEC is also the primary drug for treatment of bancroftian filariasis, we examined the long term effect of the test on microfilaraemia in 2 groups of individuals receiving either 100 mg of DEC (n = 51) or placebo (n = 20). The low dose of DEC had a significant therapeutic effect. One year after treatment, the geometric mean intensity of microfilaraemia was reduced by 86·1%, and 10·6% of the individuals were amicrofilaraemic. No significant reduction of microfilaraemia was observed in the placebo group. The results imply that the DEC provocative day test should not be used as a diagnostic tool in follow-up studies on microfilaraemias.

U2 - 10.1016/S0035-9203(97)90079-1

DO - 10.1016/S0035-9203(97)90079-1

M3 - Journal article

SN - 0035-9203

VL - 91

SP - 290

EP - 293

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 3

ER -

Bancroftian filariasis: long-term effect of the DEC provocative day test on microfilaraemia

Abstract

Access to Document

Fingerprint

Cite this