Bacteremia with the bovis group streptococci: species identification and association with infective endocarditis and with gastrointestinal disease

Ea S Marmolin; Gitte N Hartmeyer; Jens Jørgen Christensen; Xiaohui C Nielsen; Rimtas Dargis; Marianne N Skov; Elisa Knudsen; Michael Kemp; Ulrik S Justesen

doi:10.1016/j.diagmicrobio.2016.02.019

Bacteremia with the bovis group streptococci: species identification and association with infective endocarditis and with gastrointestinal disease

Ea S Marmolin, Gitte N Hartmeyer, Jens Jørgen Christensen, Xiaohui C Nielsen, Rimtas Dargis, Marianne N Skov, Elisa Knudsen, Michael Kemp, Ulrik S Justesen

20 Citations (Scopus)

Abstract

DNA sequencing of the intergenic spacer (ITS) region was used to identify 53 blood culture isolates that had previously been designated to the bovis group streptococci and clinical data was collected retrospectively from patients' records using a standardized protocol. ITS sequencing identified 19 (35.8%) isolates as Streptococcus gallolyticus subsp. gallolyticus, 12 (22.6%) as S. gallolyticus subsp. pasteurianus, two (3.8%) as S. gallolyticus subsp. macedonicus, seven (13.2%) as S. infantarius subsp. infantarius, 12 (22.6%) as S. lutetiensis and one (1.9%) as S. equinus. The association of S. gallolyticus subsp. gallolyticus with colorectal neoplasia and with infective endocarditis and the association between S. gallolyticus subsp. pasteurianus and pancreatic cancer were found to be clinically important. Also, a very high 1-year mortality rate with S. lutetiensis (66.7%) and S. gallolyticus subsp. pasteurianus (58.7%) bacteremia calls for intensive investigation for underlying disease focusing on the pancreas and the hepatobiliary system.

Original language	English
Journal	Diagnostic Microbiology and Infectious Disease
Volume	85
Issue number	2
Pages (from-to)	239-42
Number of pages	4
ISSN	0732-8893
DOIs	https://doi.org/10.1016/j.diagmicrobio.2016.02.019
Publication status	Published - 1 Jun 2016

Keywords

Aged
Aged, 80 and over
Bacteremia/microbiology
Cluster Analysis
DNA, Bacterial/chemistry
DNA, Ribosomal Spacer/chemistry
Endocarditis/epidemiology
Female
Gastrointestinal Neoplasms/epidemiology
Humans
Male
Middle Aged
Phylogeny
Retrospective Studies
Sequence Analysis, DNA
Streptococcal Infections/microbiology
Streptococcus/classification
Streptococcus bovis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2016.02.019

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Marmolin, E. S., Hartmeyer, G. N., Christensen, J. J., Nielsen, X. C., Dargis, R., Skov, M. N., Knudsen, E., Kemp, M., & Justesen, U. S. (2016). Bacteremia with the bovis group streptococci: species identification and association with infective endocarditis and with gastrointestinal disease. Diagnostic Microbiology and Infectious Disease, 85(2), 239-42. https://doi.org/10.1016/j.diagmicrobio.2016.02.019

Bacteremia with the bovis group streptococci : species identification and association with infective endocarditis and with gastrointestinal disease. / Marmolin, Ea S; Hartmeyer, Gitte N; Christensen, Jens Jørgen et al.

In: Diagnostic Microbiology and Infectious Disease, Vol. 85, No. 2, 01.06.2016, p. 239-42.

Research output: Contribution to journal › Journal article › Research › peer-review

Marmolin, ES, Hartmeyer, GN, Christensen, JJ, Nielsen, XC, Dargis, R, Skov, MN, Knudsen, E, Kemp, M & Justesen, US 2016, 'Bacteremia with the bovis group streptococci: species identification and association with infective endocarditis and with gastrointestinal disease', Diagnostic Microbiology and Infectious Disease, vol. 85, no. 2, pp. 239-42. https://doi.org/10.1016/j.diagmicrobio.2016.02.019

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abstract = "DNA sequencing of the intergenic spacer (ITS) region was used to identify 53 blood culture isolates that had previously been designated to the bovis group streptococci and clinical data was collected retrospectively from patients' records using a standardized protocol. ITS sequencing identified 19 (35.8%) isolates as Streptococcus gallolyticus subsp. gallolyticus, 12 (22.6%) as S. gallolyticus subsp. pasteurianus, two (3.8%) as S. gallolyticus subsp. macedonicus, seven (13.2%) as S. infantarius subsp. infantarius, 12 (22.6%) as S. lutetiensis and one (1.9%) as S. equinus. The association of S. gallolyticus subsp. gallolyticus with colorectal neoplasia and with infective endocarditis and the association between S. gallolyticus subsp. pasteurianus and pancreatic cancer were found to be clinically important. Also, a very high 1-year mortality rate with S. lutetiensis (66.7%) and S. gallolyticus subsp. pasteurianus (58.7%) bacteremia calls for intensive investigation for underlying disease focusing on the pancreas and the hepatobiliary system. ",

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T2 - species identification and association with infective endocarditis and with gastrointestinal disease

AU - Marmolin, Ea S

AU - Hartmeyer, Gitte N

AU - Christensen, Jens Jørgen

AU - Nielsen, Xiaohui C

AU - Dargis, Rimtas

AU - Skov, Marianne N

AU - Knudsen, Elisa

AU - Kemp, Michael

AU - Justesen, Ulrik S

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N2 - DNA sequencing of the intergenic spacer (ITS) region was used to identify 53 blood culture isolates that had previously been designated to the bovis group streptococci and clinical data was collected retrospectively from patients' records using a standardized protocol. ITS sequencing identified 19 (35.8%) isolates as Streptococcus gallolyticus subsp. gallolyticus, 12 (22.6%) as S. gallolyticus subsp. pasteurianus, two (3.8%) as S. gallolyticus subsp. macedonicus, seven (13.2%) as S. infantarius subsp. infantarius, 12 (22.6%) as S. lutetiensis and one (1.9%) as S. equinus. The association of S. gallolyticus subsp. gallolyticus with colorectal neoplasia and with infective endocarditis and the association between S. gallolyticus subsp. pasteurianus and pancreatic cancer were found to be clinically important. Also, a very high 1-year mortality rate with S. lutetiensis (66.7%) and S. gallolyticus subsp. pasteurianus (58.7%) bacteremia calls for intensive investigation for underlying disease focusing on the pancreas and the hepatobiliary system.

AB - DNA sequencing of the intergenic spacer (ITS) region was used to identify 53 blood culture isolates that had previously been designated to the bovis group streptococci and clinical data was collected retrospectively from patients' records using a standardized protocol. ITS sequencing identified 19 (35.8%) isolates as Streptococcus gallolyticus subsp. gallolyticus, 12 (22.6%) as S. gallolyticus subsp. pasteurianus, two (3.8%) as S. gallolyticus subsp. macedonicus, seven (13.2%) as S. infantarius subsp. infantarius, 12 (22.6%) as S. lutetiensis and one (1.9%) as S. equinus. The association of S. gallolyticus subsp. gallolyticus with colorectal neoplasia and with infective endocarditis and the association between S. gallolyticus subsp. pasteurianus and pancreatic cancer were found to be clinically important. Also, a very high 1-year mortality rate with S. lutetiensis (66.7%) and S. gallolyticus subsp. pasteurianus (58.7%) bacteremia calls for intensive investigation for underlying disease focusing on the pancreas and the hepatobiliary system.

KW - Aged

KW - Aged, 80 and over

KW - Bacteremia/microbiology

KW - Cluster Analysis

KW - DNA, Bacterial/chemistry

KW - DNA, Ribosomal Spacer/chemistry

KW - Endocarditis/epidemiology

KW - Female

KW - Gastrointestinal Neoplasms/epidemiology

KW - Humans

KW - Male

KW - Middle Aged

KW - Phylogeny

KW - Retrospective Studies

KW - Sequence Analysis, DNA

KW - Streptococcal Infections/microbiology

KW - Streptococcus/classification

KW - Streptococcus bovis

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DO - 10.1016/j.diagmicrobio.2016.02.019

M3 - Journal article

C2 - 27117515

SN - 0732-8893

VL - 85

SP - 239

EP - 242

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 2

ER -

Bacteremia with the bovis group streptococci: species identification and association with infective endocarditis and with gastrointestinal disease

Abstract

Keywords

UN SDGs

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