Bacteremia with the bovis group streptococci: species identification and association with infective endocarditis and with gastrointestinal disease

TY - JOUR

T1 - Bacteremia with the bovis group streptococci

T2 - species identification and association with infective endocarditis and with gastrointestinal disease

AU - Marmolin, Ea S

AU - Hartmeyer, Gitte N

AU - Christensen, Jens Jørgen

AU - Nielsen, Xiaohui C

AU - Dargis, Rimtas

AU - Skov, Marianne N

AU - Knudsen, Elisa

AU - Kemp, Michael

AU - Justesen, Ulrik S

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - DNA sequencing of the intergenic spacer (ITS) region was used to identify 53 blood culture isolates that had previously been designated to the bovis group streptococci and clinical data was collected retrospectively from patients' records using a standardized protocol. ITS sequencing identified 19 (35.8%) isolates as Streptococcus gallolyticus subsp. gallolyticus, 12 (22.6%) as S. gallolyticus subsp. pasteurianus, two (3.8%) as S. gallolyticus subsp. macedonicus, seven (13.2%) as S. infantarius subsp. infantarius, 12 (22.6%) as S. lutetiensis and one (1.9%) as S. equinus. The association of S. gallolyticus subsp. gallolyticus with colorectal neoplasia and with infective endocarditis and the association between S. gallolyticus subsp. pasteurianus and pancreatic cancer were found to be clinically important. Also, a very high 1-year mortality rate with S. lutetiensis (66.7%) and S. gallolyticus subsp. pasteurianus (58.7%) bacteremia calls for intensive investigation for underlying disease focusing on the pancreas and the hepatobiliary system.

AB - DNA sequencing of the intergenic spacer (ITS) region was used to identify 53 blood culture isolates that had previously been designated to the bovis group streptococci and clinical data was collected retrospectively from patients' records using a standardized protocol. ITS sequencing identified 19 (35.8%) isolates as Streptococcus gallolyticus subsp. gallolyticus, 12 (22.6%) as S. gallolyticus subsp. pasteurianus, two (3.8%) as S. gallolyticus subsp. macedonicus, seven (13.2%) as S. infantarius subsp. infantarius, 12 (22.6%) as S. lutetiensis and one (1.9%) as S. equinus. The association of S. gallolyticus subsp. gallolyticus with colorectal neoplasia and with infective endocarditis and the association between S. gallolyticus subsp. pasteurianus and pancreatic cancer were found to be clinically important. Also, a very high 1-year mortality rate with S. lutetiensis (66.7%) and S. gallolyticus subsp. pasteurianus (58.7%) bacteremia calls for intensive investigation for underlying disease focusing on the pancreas and the hepatobiliary system.

KW - Aged

KW - Aged, 80 and over

KW - Bacteremia/microbiology

KW - Cluster Analysis

KW - DNA, Bacterial/chemistry

KW - DNA, Ribosomal Spacer/chemistry

KW - Endocarditis/epidemiology

KW - Female

KW - Gastrointestinal Neoplasms/epidemiology

KW - Humans

KW - Male

KW - Middle Aged

KW - Phylogeny

KW - Retrospective Studies

KW - Sequence Analysis, DNA

KW - Streptococcal Infections/microbiology

KW - Streptococcus/classification

KW - Streptococcus bovis

U2 - 10.1016/j.diagmicrobio.2016.02.019

DO - 10.1016/j.diagmicrobio.2016.02.019

M3 - Journal article

C2 - 27117515

SN - 0732-8893

VL - 85

SP - 239

EP - 242

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 2

ER -