Back to the roots: deep view into the evolutionary history of ADP-ribosylation opened by the DNA-targeting toxin-antitoxin module DarTG

Alexander Harms; Kenn Gerdes

doi:10.1016/j.molcel.2016.11.038

Back to the roots: deep view into the evolutionary history of ADP-ribosylation opened by the DNA-targeting toxin-antitoxin module DarTG

Alexander Harms, Kenn Gerdes^*

^*Corresponding author for this work

Functional Genomics

2 Citations (Scopus)

Abstract

In this issue of Molecular Cell, Jankevicius et al. (2016) characterize the DarTG toxin-antitoxin module in which the DarT toxin ADP-ribosylates single-stranded DNA and the DarG antitoxin counteracts DarT by direct binding and by enzymatic removal of the ADP-ribosylation.

Original language	English
Journal	Molecular Cell
Volume	64
Issue number	6
Pages (from-to)	1020-1021
Number of pages	2
ISSN	1097-2765
DOIs	https://doi.org/10.1016/j.molcel.2016.11.038
Publication status	Published - 15 Dec 2016

Keywords

ADP-ribosylation
bacterial persistence
DarG
DarT
restriction-modification system
toxin-antitoxin module

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10.1016/j.molcel.2016.11.038

http://www.cell.com/article/S1097276516308115/pdf

Cite this

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title = "Back to the roots: deep view into the evolutionary history of ADP-ribosylation opened by the DNA-targeting toxin-antitoxin module DarTG",

abstract = "In this issue of Molecular Cell, Jankevicius et al. (2016) characterize the DarTG toxin-antitoxin module in which the DarT toxin ADP-ribosylates single-stranded DNA and the DarG antitoxin counteracts DarT by direct binding and by enzymatic removal of the ADP-ribosylation.",

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AU - Gerdes, Kenn

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N2 - In this issue of Molecular Cell, Jankevicius et al. (2016) characterize the DarTG toxin-antitoxin module in which the DarT toxin ADP-ribosylates single-stranded DNA and the DarG antitoxin counteracts DarT by direct binding and by enzymatic removal of the ADP-ribosylation.

AB - In this issue of Molecular Cell, Jankevicius et al. (2016) characterize the DarTG toxin-antitoxin module in which the DarT toxin ADP-ribosylates single-stranded DNA and the DarG antitoxin counteracts DarT by direct binding and by enzymatic removal of the ADP-ribosylation.

KW - ADP-ribosylation

KW - bacterial persistence

KW - DarG

KW - DarT

KW - restriction-modification system

KW - toxin-antitoxin module

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AN - SCOPUS:85008231221

SN - 1097-2765

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ER -

Back to the roots: deep view into the evolutionary history of ADP-ribosylation opened by the DNA-targeting toxin-antitoxin module DarTG

Abstract

Keywords

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