Back to the roots: deep view into the evolutionary history of ADP-ribosylation opened by the DNA-targeting toxin-antitoxin module DarTG

Alexander Harms; Kenn Gerdes

doi:10.1016/j.molcel.2016.11.038

Back to the roots: deep view into the evolutionary history of ADP-ribosylation opened by the DNA-targeting toxin-antitoxin module DarTG

Alexander Harms, Kenn Gerdes^*

^*Corresponding author af dette arbejde

Functional genomics

2 Citationer (Scopus)

Abstract

In this issue of Molecular Cell, Jankevicius et al. (2016) characterize the DarTG toxin-antitoxin module in which the DarT toxin ADP-ribosylates single-stranded DNA and the DarG antitoxin counteracts DarT by direct binding and by enzymatic removal of the ADP-ribosylation.

Originalsprog	Engelsk
Tidsskrift	Molecular Cell
Vol/bind	64
Udgave nummer	6
Sider (fra-til)	1020-1021
Antal sider	2
ISSN	1097-2765
DOI	https://doi.org/10.1016/j.molcel.2016.11.038
Status	Udgivet - 15 dec. 2016

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10.1016/j.molcel.2016.11.038

http://www.cell.com/article/S1097276516308115/pdf

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abstract = "In this issue of Molecular Cell, Jankevicius et al. (2016) characterize the DarTG toxin-antitoxin module in which the DarT toxin ADP-ribosylates single-stranded DNA and the DarG antitoxin counteracts DarT by direct binding and by enzymatic removal of the ADP-ribosylation.",

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AU - Gerdes, Kenn

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KW - ADP-ribosylation

KW - bacterial persistence

KW - DarG

KW - DarT

KW - restriction-modification system

KW - toxin-antitoxin module

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Back to the roots: deep view into the evolutionary history of ADP-ribosylation opened by the DNA-targeting toxin-antitoxin module DarTG

Abstract

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