TY - JOUR
T1 - Atypical myopathy in Denmark confirmed with the aTRAQ assay
AU - Høffer, Sofie Esbjørn
AU - Votion, Dominique-Marie
AU - Anderberg, Marie
AU - Boemer, Francois
AU - Olsen, Susanne Nautrup
AU - van Galen Verwilghen, Gaby
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Atypical myopathy is a severe form of rhabdomyolysis that occurs in grazing horses. Over the past decades, the disease has been emerging in Europe. The disease is widespread in Europe and has been suspected in Denmark since 2000, yet no cases have been confirmed. The objective of this study was to confirm cases in this country and to use a new diagnostic technique (aTRAQ assay). Seven out of 8 samples from clinically highly suspicious cases were positive for hypoglycin A, and all had multiple acyl-CoA dehydrogenase deficiency, which confirms that the disease is also present in Denmark. Hypoglycin A levels were lower and clinical signs and mortality less severe than reported in other countries.
AB - Atypical myopathy is a severe form of rhabdomyolysis that occurs in grazing horses. Over the past decades, the disease has been emerging in Europe. The disease is widespread in Europe and has been suspected in Denmark since 2000, yet no cases have been confirmed. The objective of this study was to confirm cases in this country and to use a new diagnostic technique (aTRAQ assay). Seven out of 8 samples from clinically highly suspicious cases were positive for hypoglycin A, and all had multiple acyl-CoA dehydrogenase deficiency, which confirms that the disease is also present in Denmark. Hypoglycin A levels were lower and clinical signs and mortality less severe than reported in other countries.
U2 - 10.1016/j.jevs.2016.08.010
DO - 10.1016/j.jevs.2016.08.010
M3 - Letter
SN - 0737-0806
VL - 47
SP - 77
EP - 79
JO - Journal of Equine Veterinary Science
JF - Journal of Equine Veterinary Science
ER -