Atypical myopathy in Denmark confirmed with the aTRAQ assay

Sofie Esbjørn Høffer; Dominique-Marie Votion; Marie Anderberg; Francois Boemer; Susanne Nautrup Olsen; Gaby van Galen Verwilghen

doi:10.1016/j.jevs.2016.08.010

Atypical myopathy in Denmark confirmed with the aTRAQ assay

Sofie Esbjørn Høffer, Dominique-Marie Votion, Marie Anderberg, Francois Boemer, Susanne Nautrup Olsen, Gaby van Galen Verwilghen

1 Citationer (Scopus)

Abstract

Atypical myopathy is a severe form of rhabdomyolysis that occurs in grazing horses. Over the past decades, the disease has been emerging in Europe. The disease is widespread in Europe and has been suspected in Denmark since 2000, yet no cases have been confirmed. The objective of this study was to confirm cases in this country and to use a new diagnostic technique (aTRAQ assay). Seven out of 8 samples from clinically highly suspicious cases were positive for hypoglycin A, and all had multiple acyl-CoA dehydrogenase deficiency, which confirms that the disease is also present in Denmark. Hypoglycin A levels were lower and clinical signs and mortality less severe than reported in other countries.

Originalsprog	Engelsk
Tidsskrift	Journal of Equine Veterinary Science
Vol/bind	47
Sider (fra-til)	77 - 79
Antal sider	3
ISSN	0737-0806
DOI	https://doi.org/10.1016/j.jevs.2016.08.010
Status	Udgivet - 1 dec. 2016

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10.1016/j.jevs.2016.08.010

Citationsformater

Høffer, S. E., Votion, D.-M., Anderberg, M., Boemer, F., Olsen, S. N., & van Galen Verwilghen, G. (2016). Atypical myopathy in Denmark confirmed with the aTRAQ assay. Journal of Equine Veterinary Science, 47, 77 - 79. https://doi.org/10.1016/j.jevs.2016.08.010

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title = "Atypical myopathy in Denmark confirmed with the aTRAQ assay",

abstract = "Atypical myopathy is a severe form of rhabdomyolysis that occurs in grazing horses. Over the past decades, the disease has been emerging in Europe. The disease is widespread in Europe and has been suspected in Denmark since 2000, yet no cases have been confirmed. The objective of this study was to confirm cases in this country and to use a new diagnostic technique (aTRAQ assay). Seven out of 8 samples from clinically highly suspicious cases were positive for hypoglycin A, and all had multiple acyl-CoA dehydrogenase deficiency, which confirms that the disease is also present in Denmark. Hypoglycin A levels were lower and clinical signs and mortality less severe than reported in other countries.",

author = "H{\o}ffer, {Sofie Esbj{\o}rn} and Dominique-Marie Votion and Marie Anderberg and Francois Boemer and Olsen, {Susanne Nautrup} and {van Galen Verwilghen}, Gaby",

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doi = "10.1016/j.jevs.2016.08.010",

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T1 - Atypical myopathy in Denmark confirmed with the aTRAQ assay

AU - Høffer, Sofie Esbjørn

AU - Votion, Dominique-Marie

AU - Anderberg, Marie

AU - Boemer, Francois

AU - Olsen, Susanne Nautrup

AU - van Galen Verwilghen, Gaby

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Atypical myopathy is a severe form of rhabdomyolysis that occurs in grazing horses. Over the past decades, the disease has been emerging in Europe. The disease is widespread in Europe and has been suspected in Denmark since 2000, yet no cases have been confirmed. The objective of this study was to confirm cases in this country and to use a new diagnostic technique (aTRAQ assay). Seven out of 8 samples from clinically highly suspicious cases were positive for hypoglycin A, and all had multiple acyl-CoA dehydrogenase deficiency, which confirms that the disease is also present in Denmark. Hypoglycin A levels were lower and clinical signs and mortality less severe than reported in other countries.

AB - Atypical myopathy is a severe form of rhabdomyolysis that occurs in grazing horses. Over the past decades, the disease has been emerging in Europe. The disease is widespread in Europe and has been suspected in Denmark since 2000, yet no cases have been confirmed. The objective of this study was to confirm cases in this country and to use a new diagnostic technique (aTRAQ assay). Seven out of 8 samples from clinically highly suspicious cases were positive for hypoglycin A, and all had multiple acyl-CoA dehydrogenase deficiency, which confirms that the disease is also present in Denmark. Hypoglycin A levels were lower and clinical signs and mortality less severe than reported in other countries.

U2 - 10.1016/j.jevs.2016.08.010

DO - 10.1016/j.jevs.2016.08.010

M3 - Letter

SN - 0737-0806

VL - 47

SP - 77

EP - 79

JO - Journal of Equine Veterinary Science

JF - Journal of Equine Veterinary Science

ER -

Atypical myopathy in Denmark confirmed with the aTRAQ assay

Abstract

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