Astrocytes take the stage in a tale of signaling-metabolism coupling

Lasse K Bak

doi:10.1074/jbc.H117.777243

Astrocytes take the stage in a tale of signaling-metabolism coupling

Lasse K Bak

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Abstract

Astrocytes are crucial cells in the brain that are intimately coupled with neuronal metabolism. A new paper from San Martín et al. provides evidence that physiological levels of the gaseous signal molecule NO can rapidly and reversibly increase astrocyte metabolism of glucose and production of lactate. A proposed neurological coupling-from the potential source of NO, endothelial cells, to the potential beneficiary from the lactate, neurons-prompts new questions regarding the controversial role of lactate in the brain.

Original language	English
Journal	The Journal of Biological Chemistry
Volume	292
Issue number	22
Pages (from-to)	9439-9440
Number of pages	2
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.H117.777243
Publication status	Published - 2 Jun 2017

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Journal Article

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abstract = "Astrocytes are crucial cells in the brain that are intimately coupled with neuronal metabolism. A new paper from San Mart{\'i}n et al. provides evidence that physiological levels of the gaseous signal molecule NO can rapidly and reversibly increase astrocyte metabolism of glucose and production of lactate. A proposed neurological coupling-from the potential source of NO, endothelial cells, to the potential beneficiary from the lactate, neurons-prompts new questions regarding the controversial role of lactate in the brain.",

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Astrocytes take the stage in a tale of signaling-metabolism coupling

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