Astrocytes take the stage in a tale of signaling-metabolism coupling

Lasse K Bak

doi:10.1074/jbc.H117.777243

Astrocytes take the stage in a tale of signaling-metabolism coupling

Lasse K Bak

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Abstract

Astrocytes are crucial cells in the brain that are intimately coupled with neuronal metabolism. A new paper from San Martín et al. provides evidence that physiological levels of the gaseous signal molecule NO can rapidly and reversibly increase astrocyte metabolism of glucose and production of lactate. A proposed neurological coupling-from the potential source of NO, endothelial cells, to the potential beneficiary from the lactate, neurons-prompts new questions regarding the controversial role of lactate in the brain.

Originalsprog	Engelsk
Tidsskrift	The Journal of Biological Chemistry
Vol/bind	292
Udgave nummer	22
Sider (fra-til)	9439-9440
Antal sider	2
ISSN	0021-9258
DOI	https://doi.org/10.1074/jbc.H117.777243
Status	Udgivet - 2 jun. 2017

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10.1074/jbc.H117.777243Licens: Ikke-specificeret

J. Biol. Chem.-2017-Bak-9439-40Licens: Ikke-specificeret

Citationsformater

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Astrocytes take the stage in a tale of signaling-metabolism coupling

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