Association between the intake of α-linolenic acid and the risk of CHD

Mia Sadowa Vedtofte; Marianne U Jakobsen; Lotte Lauritzen; Eilis J O'Reilly; Jarmo Virtamo; Paul Knekt; Graham Colditz; Göran Hallmans; Julie Buring; Lyn M Steffen; Kimberly Robien; Eric B Rimm; Berit L Heitmann

doi:10.1017/S000711451400138X

Association between the intake of α-linolenic acid and the risk of CHD

Mia Sadowa Vedtofte, Marianne U Jakobsen, Lotte Lauritzen, Eilis J O'Reilly, Jarmo Virtamo, Paul Knekt, Graham Colditz, Göran Hallmans, Julie Buring, Lyn M Steffen, Kimberly Robien, Eric B Rimm, Berit L Heitmann

15 Citations (Scopus)

Abstract

The intake of the mainly plant-derived n-3 PUFA α-linolenic acid (ALA) has been reported to be associated with a lower risk of CHD. However, the results have been inconsistent. Therefore, the objective of the present study was to examine the association between the intake of ALA and the risk of CHD. Potential effect modification by the intake of long-chain n-3 PUFA (n-3 LCPUFA) was also investigated. Data from eight American and European prospective cohort studies including 148 675 women and 80 368 men were used. The outcome measure was incident CHD (CHD event and death). During 4-10 years of follow-up, 4493 CHD events and 1751 CHD deaths occurred. Among men, an inverse association (not significant) between the intake of ALA and the risk of CHD events and deaths was observed. For each additional gram of ALA consumed, a 15 % lower risk of CHD events (hazard ratios (HR) 0·85, 95 % CI 0·72, 1·01) and a 23 % lower risk of CHD deaths (HR 0·77, 95 % CI 0·58, 1·01) were observed. No consistent association was observed among women. No effect modification by the intake of n-3 LCPUFA was observed.

Original language	English
Journal	British Journal of Nutrition
Volume	112
Issue number	5
Pages (from-to)	735-743
Number of pages	9
ISSN	0007-1145
DOIs	https://doi.org/10.1017/S000711451400138X
Publication status	Published - 14 Sept 2014

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title = "Association between the intake of α-linolenic acid and the risk of CHD",

abstract = "The intake of the mainly plant-derived n-3 PUFA α-linolenic acid (ALA) has been reported to be associated with a lower risk of CHD. However, the results have been inconsistent. Therefore, the objective of the present study was to examine the association between the intake of ALA and the risk of CHD. Potential effect modification by the intake of long-chain n-3 PUFA (n-3 LCPUFA) was also investigated. Data from eight American and European prospective cohort studies including 148 675 women and 80 368 men were used. The outcome measure was incident CHD (CHD event and death). During 4-10 years of follow-up, 4493 CHD events and 1751 CHD deaths occurred. Among men, an inverse association (not significant) between the intake of ALA and the risk of CHD events and deaths was observed. For each additional gram of ALA consumed, a 15 % lower risk of CHD events (hazard ratios (HR) 0·85, 95 % CI 0·72, 1·01) and a 23 % lower risk of CHD deaths (HR 0·77, 95 % CI 0·58, 1·01) were observed. No consistent association was observed among women. No effect modification by the intake of n-3 LCPUFA was observed.",

author = "Vedtofte, {Mia Sadowa} and Jakobsen, {Marianne U} and Lotte Lauritzen and O'Reilly, {Eilis J} and Jarmo Virtamo and Paul Knekt and Graham Colditz and G{\"o}ran Hallmans and Julie Buring and Steffen, {Lyn M} and Kimberly Robien and Rimm, {Eric B} and Heitmann, {Berit L}",

note = "CURSI 2014 NEXS 210",

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doi = "10.1017/S000711451400138X",

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T1 - Association between the intake of α-linolenic acid and the risk of CHD

AU - Vedtofte, Mia Sadowa

AU - Jakobsen, Marianne U

AU - Lauritzen, Lotte

AU - O'Reilly, Eilis J

AU - Virtamo, Jarmo

AU - Knekt, Paul

AU - Colditz, Graham

AU - Hallmans, Göran

AU - Buring, Julie

AU - Steffen, Lyn M

AU - Robien, Kimberly

AU - Rimm, Eric B

AU - Heitmann, Berit L

N1 - CURSI 2014 NEXS 210

PY - 2014/9/14

Y1 - 2014/9/14

N2 - The intake of the mainly plant-derived n-3 PUFA α-linolenic acid (ALA) has been reported to be associated with a lower risk of CHD. However, the results have been inconsistent. Therefore, the objective of the present study was to examine the association between the intake of ALA and the risk of CHD. Potential effect modification by the intake of long-chain n-3 PUFA (n-3 LCPUFA) was also investigated. Data from eight American and European prospective cohort studies including 148 675 women and 80 368 men were used. The outcome measure was incident CHD (CHD event and death). During 4-10 years of follow-up, 4493 CHD events and 1751 CHD deaths occurred. Among men, an inverse association (not significant) between the intake of ALA and the risk of CHD events and deaths was observed. For each additional gram of ALA consumed, a 15 % lower risk of CHD events (hazard ratios (HR) 0·85, 95 % CI 0·72, 1·01) and a 23 % lower risk of CHD deaths (HR 0·77, 95 % CI 0·58, 1·01) were observed. No consistent association was observed among women. No effect modification by the intake of n-3 LCPUFA was observed.

AB - The intake of the mainly plant-derived n-3 PUFA α-linolenic acid (ALA) has been reported to be associated with a lower risk of CHD. However, the results have been inconsistent. Therefore, the objective of the present study was to examine the association between the intake of ALA and the risk of CHD. Potential effect modification by the intake of long-chain n-3 PUFA (n-3 LCPUFA) was also investigated. Data from eight American and European prospective cohort studies including 148 675 women and 80 368 men were used. The outcome measure was incident CHD (CHD event and death). During 4-10 years of follow-up, 4493 CHD events and 1751 CHD deaths occurred. Among men, an inverse association (not significant) between the intake of ALA and the risk of CHD events and deaths was observed. For each additional gram of ALA consumed, a 15 % lower risk of CHD events (hazard ratios (HR) 0·85, 95 % CI 0·72, 1·01) and a 23 % lower risk of CHD deaths (HR 0·77, 95 % CI 0·58, 1·01) were observed. No consistent association was observed among women. No effect modification by the intake of n-3 LCPUFA was observed.

U2 - 10.1017/S000711451400138X

DO - 10.1017/S000711451400138X

M3 - Journal article

C2 - 24964401

SN - 0007-1145

VL - 112

SP - 735

EP - 743

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 5

ER -

Association between the intake of α-linolenic acid and the risk of CHD

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