Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review

Lecia M Nielsen; Anne Estrup Olesen; Ruth Branford; Lona Louring Christrup; Hiroe Sato; Asbjørn M Drewes

doi:10.1111/papr.12232

Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review

Lecia M Nielsen, Anne Estrup Olesen, Ruth Branford, Lona Louring Christrup, Hiroe Sato, Asbjørn M Drewes

39 Citations (Scopus)

Abstract

On an individual level, there is a difference in the analgesic response to a given opioid. Various factors such as gender, age, and genetic variation can affect the analgesic response. The genetic variation can influence pharmacokinetics (eg drug transporters and drug-metabolizing enzymes) and/or pharmacodynamics (eg opioid receptor and catechol-O-methyltransferase enzymes). We present recent experimentally induced pain, postoperative pain, and cancer pain and chronic non-malignant pain conditions studies in humans, focusing on the association between genetic variation and analgesic response assessed as opioid consumption or changes in pain scores. Studies have shown promising results regarding pharmacogenetics as a diagnostic tool for predicting the individual response to a given opioid in the experimental settings; however, in the clinic, it is a more complicated task to accomplish.

Original language	English
Journal	Pain Practice
Volume	15
Issue number	6
Pages (from-to)	580–594
Number of pages	15
ISSN	1530-7085
DOIs	https://doi.org/10.1111/papr.12232
Publication status	Published - 1 Jul 2015

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title = "Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review",

abstract = "On an individual level, there is a difference in the analgesic response to a given opioid. Various factors such as gender, age, and genetic variation can affect the analgesic response. The genetic variation can influence pharmacokinetics (eg drug transporters and drug-metabolizing enzymes) and/or pharmacodynamics (eg opioid receptor and catechol-O-methyltransferase enzymes). We present recent experimentally induced pain, postoperative pain, and cancer pain and chronic non-malignant pain conditions studies in humans, focusing on the association between genetic variation and analgesic response assessed as opioid consumption or changes in pain scores. Studies have shown promising results regarding pharmacogenetics as a diagnostic tool for predicting the individual response to a given opioid in the experimental settings; however, in the clinic, it is a more complicated task to accomplish.",

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AU - Nielsen, Lecia M

AU - Olesen, Anne Estrup

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AU - Christrup, Lona Louring

AU - Sato, Hiroe

AU - Drewes, Asbjørn M

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Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review

Abstract

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