Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy

Z Shamim; K Müller; A Svejgaard; Lars K. Poulsen; U Bodtger; L P Ryder

doi:10.1111/j.1744-313X.2007.00657.x

Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy

Z Shamim, K Müller, A Svejgaard, Lars K. Poulsen, U Bodtger, L P Ryder

32 Citations (Scopus)

Abstract

Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

Original language	English
Journal	International Journal of Immunogenetics (Print Edition)
Volume	34
Issue number	3
Pages (from-to)	149-51
Number of pages	3
ISSN	1744-3121
DOIs	https://doi.org/10.1111/j.1744-313X.2007.00657.x
Publication status	Published - 2007

Keywords

Adult
Case-Control Studies
Denmark
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Interleukin-7
Respiratory Hypersensitivity

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10.1111/j.1744-313X.2007.00657.x

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title = "Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy",

abstract = "Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.",

keywords = "Adult, Case-Control Studies, Denmark, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Interleukin-7, Respiratory Hypersensitivity",

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year = "2007",

doi = "10.1111/j.1744-313X.2007.00657.x",

language = "English",

volume = "34",

pages = "149--51",

journal = "International Journal of Immunogenetics",

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T1 - Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy

AU - Shamim, Z

AU - Müller, K

AU - Svejgaard, A

AU - Poulsen, Lars K.

AU - Bodtger, U

AU - Ryder, L P

PY - 2007

Y1 - 2007

N2 - Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

AB - Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

KW - Adult

KW - Case-Control Studies

KW - Denmark

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Receptors, Interleukin-7

KW - Respiratory Hypersensitivity

U2 - 10.1111/j.1744-313X.2007.00657.x

DO - 10.1111/j.1744-313X.2007.00657.x

M3 - Journal article

C2 - 17504502

SN - 1744-3121

VL - 34

SP - 149

EP - 151

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

IS - 3

ER -

Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy

Abstract

Keywords

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