Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy

TY - JOUR

T1 - Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy

AU - Shamim, Z

AU - Müller, K

AU - Svejgaard, A

AU - Poulsen, Lars K.

AU - Bodtger, U

AU - Ryder, L P

PY - 2007

Y1 - 2007

N2 - Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

AB - Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

KW - Adult

KW - Case-Control Studies

KW - Denmark

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Receptors, Interleukin-7

KW - Respiratory Hypersensitivity

U2 - 10.1111/j.1744-313X.2007.00657.x

DO - 10.1111/j.1744-313X.2007.00657.x

M3 - Journal article

C2 - 17504502

SN - 1744-3121

VL - 34

SP - 149

EP - 151

JO - International Journal of Immunogenetics (Print Edition)

JF - International Journal of Immunogenetics (Print Edition)

IS - 3

ER -