Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples

Martin Tesli; Pernille Koefoed; Lavinia Athanasiu; Morten Mattingsdal; Omar Gustafsson; Ingrid Agartz; Lars M Rimol; Andrew Brown; Katrine V Wirgenes; Lisa-Lena Smorr; Anna K Kähler; Thomas Werge; Ole Mors; Erling Mellerup; Erik G Jönsson; Ingrid Melle; Gunnar Morken; Srdjan Djurovic; Ole A Andreassen

doi:10.1002/ajmg.b.31244

Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples

Martin Tesli, Pernille Koefoed, Lavinia Athanasiu, Morten Mattingsdal, Omar Gustafsson, Ingrid Agartz, Lars M Rimol, Andrew Brown, Katrine V Wirgenes, Lisa-Lena Smorr, Anna K Kähler, Thomas Werge, Ole Mors, Erling Mellerup, Erik G Jönsson, Ingrid Melle, Gunnar Morken, Srdjan Djurovic, Ole A Andreassen

26 Citations (Scopus)

Abstract

Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case-control sample (N=854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case-control sample (N=1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N=435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N=1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P=0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P=0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case-control sample (N=1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved.

Original language	English
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	156
Issue number	8
Pages (from-to)	969-74
Number of pages	6
ISSN	1552-4841
DOIs	https://doi.org/10.1002/ajmg.b.31244
Publication status	Published - 1 Dec 2011

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Tesli, M., Koefoed, P., Athanasiu, L., Mattingsdal, M., Gustafsson, O., Agartz, I., Rimol, L. M., Brown, A., Wirgenes, K. V., Smorr, L.-L., Kähler, A. K., Werge, T., Mors, O., Mellerup, E., Jönsson, E. G., Melle, I., Morken, G., Djurovic, S., & Andreassen, O. A. (2011). Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 156(8), 969-74. https://doi.org/10.1002/ajmg.b.31244

Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. / Tesli, Martin; Koefoed, Pernille; Athanasiu, Lavinia et al.
In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol. 156, No. 8, 01.12.2011, p. 969-74.

Research output: Contribution to journal › Journal article › Research › peer-review

Tesli, M, Koefoed, P, Athanasiu, L, Mattingsdal, M, Gustafsson, O, Agartz, I, Rimol, LM, Brown, A, Wirgenes, KV, Smorr, L-L, Kähler, AK, Werge, T, Mors, O, Mellerup, E, Jönsson, EG, Melle, I, Morken, G, Djurovic, S & Andreassen, OA 2011, 'Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 156, no. 8, pp. 969-74. https://doi.org/10.1002/ajmg.b.31244

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title = "Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples",

abstract = "Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case-control sample (N=854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case-control sample (N=1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N=435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N=1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P=0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P=0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case-control sample (N=1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved.",

author = "Martin Tesli and Pernille Koefoed and Lavinia Athanasiu and Morten Mattingsdal and Omar Gustafsson and Ingrid Agartz and Rimol, {Lars M} and Andrew Brown and Wirgenes, {Katrine V} and Lisa-Lena Smorr and K{\"a}hler, {Anna K} and Thomas Werge and Ole Mors and Erling Mellerup and J{\"o}nsson, {Erik G} and Ingrid Melle and Gunnar Morken and Srdjan Djurovic and Andreassen, {Ole A}",

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AU - Tesli, Martin

AU - Koefoed, Pernille

AU - Athanasiu, Lavinia

AU - Mattingsdal, Morten

AU - Gustafsson, Omar

AU - Agartz, Ingrid

AU - Rimol, Lars M

AU - Brown, Andrew

AU - Wirgenes, Katrine V

AU - Smorr, Lisa-Lena

AU - Kähler, Anna K

AU - Werge, Thomas

AU - Mors, Ole

AU - Mellerup, Erling

AU - Jönsson, Erik G

AU - Melle, Ingrid

AU - Morken, Gunnar

AU - Djurovic, Srdjan

AU - Andreassen, Ole A

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case-control sample (N=854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case-control sample (N=1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N=435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N=1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P=0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P=0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case-control sample (N=1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved.

AB - Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case-control sample (N=854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case-control sample (N=1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N=435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N=1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P=0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P=0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case-control sample (N=1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved.

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DO - 10.1002/ajmg.b.31244

M3 - Journal article

C2 - 21972176

SN - 1552-4841

VL - 156

SP - 969

EP - 974

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 8

ER -

Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples

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