Are microRNAs located in genomic regions associated with cancer?

P. Lamy; C. L. Andersen; L. Dyrskjøt; N. Tørring; T. Ørntoft; C. Wiuf

doi:10.1038/sj.bjc.6603381

Are microRNAs located in genomic regions associated with cancer?

P. Lamy, C. L. Andersen, L. Dyrskjøt, N. Tørring, T. Ørntoft, C. Wiuf^*

^*Corresponding author for this work

37 Citations (Scopus)

Abstract

We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.

Original language	English
Journal	British Journal of Cancer
Volume	95
Issue number	10
Pages (from-to)	1415-1418
Number of pages	4
ISSN	0007-0920
DOIs	https://doi.org/10.1038/sj.bjc.6603381
Publication status	Published - 20 Nov 2006
Externally published	Yes

Keywords

Affymetrix SNP array
Bladder
Colon
Copy number
microRNA
Prostate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/sj.bjc.6603381

Cite this

@article{4a36577096c546dba70b86e887dfdef0,

title = "Are microRNAs located in genomic regions associated with cancer?",

abstract = "We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.",

keywords = "Affymetrix SNP array, Bladder, Colon, Copy number, microRNA, Prostate",

author = "P. Lamy and Andersen, {C. L.} and L. Dyrskj{\o}t and N. T{\o}rring and T. {\O}rntoft and C. Wiuf",

year = "2006",

month = nov,

day = "20",

doi = "10.1038/sj.bjc.6603381",

language = "English",

volume = "95",

pages = "1415--1418",

journal = "The British journal of cancer. Supplement",

issn = "0007-0920",