Are microRNAs located in genomic regions associated with cancer?

P. Lamy; C. L. Andersen; L. Dyrskjøt; N. Tørring; T. Ørntoft; C. Wiuf

doi:10.1038/sj.bjc.6603381

Are microRNAs located in genomic regions associated with cancer?

P. Lamy, C. L. Andersen, L. Dyrskjøt, N. Tørring, T. Ørntoft, C. Wiuf^*

^*Corresponding author af dette arbejde

37 Citationer (Scopus)

Abstract

We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.

Originalsprog	Engelsk
Tidsskrift	British Journal of Cancer
Vol/bind	95
Udgave nummer	10
Sider (fra-til)	1415-1418
Antal sider	4
ISSN	0007-0920
DOI	https://doi.org/10.1038/sj.bjc.6603381
Status	Udgivet - 20 nov. 2006
Udgivet eksternt	Ja

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10.1038/sj.bjc.6603381

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Citationsformater

@article{4a36577096c546dba70b86e887dfdef0,

title = "Are microRNAs located in genomic regions associated with cancer?",

abstract = "We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.",

keywords = "Affymetrix SNP array, Bladder, Colon, Copy number, microRNA, Prostate",

author = "P. Lamy and Andersen, {C. L.} and L. Dyrskj{\o}t and N. T{\o}rring and T. {\O}rntoft and C. Wiuf",

year = "2006",

month = nov,

day = "20",

doi = "10.1038/sj.bjc.6603381",

language = "English",

volume = "95",

pages = "1415--1418",

journal = "The British journal of cancer. Supplement",

issn = "0007-0920",