ApoM: gene regulation and effects on HDL metabolism

Lars B Nielsen; Christina Christoffersen; Josefin Ahnström; Björn Dahlbäck

doi:10.1016/j.tem.2008.11.003

ApoM: gene regulation and effects on HDL metabolism

Lars B Nielsen, Christina Christoffersen, Josefin Ahnström, Björn Dahlbäck

Physiology of circulation, kidney and lung

29 Citations (Scopus)

Abstract

The recently discovered apolipoprotein M (apoM) is a plasma protein of the lipocalin family associated with the lipoproteins (mainly high-density lipoproteins, or HDLs). Expression of the apoM gene in the liver is regulated by transcription factors that control key steps in hepatic lipid and glucose metabolism. Although the concentration of plasma apoM correlates with that of cholesterol, apoM was not identified as a risk factor for cardiovascular disease in two prospective studies. In genetically modified mice, however, changes in plasma apoM concentration caused quantitative and qualitative changes in HDLs, and overexpression of the apoM gene reduced atherosclerosis. In conclusion, it seems that apoM plays a part in lipoprotein metabolism; however, the biological impact of apoM in humans remains to be determined.

Original language	English
Journal	Trends in Endocrinology and Metabolism
Volume	20
Issue number	2
Pages (from-to)	66-71
Number of pages	5
ISSN	1043-2760
DOIs	https://doi.org/10.1016/j.tem.2008.11.003
Publication status	Published - 2009

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10.1016/j.tem.2008.11.003

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title = "ApoM: gene regulation and effects on HDL metabolism",

abstract = "The recently discovered apolipoprotein M (apoM) is a plasma protein of the lipocalin family associated with the lipoproteins (mainly high-density lipoproteins, or HDLs). Expression of the apoM gene in the liver is regulated by transcription factors that control key steps in hepatic lipid and glucose metabolism. Although the concentration of plasma apoM correlates with that of cholesterol, apoM was not identified as a risk factor for cardiovascular disease in two prospective studies. In genetically modified mice, however, changes in plasma apoM concentration caused quantitative and qualitative changes in HDLs, and overexpression of the apoM gene reduced atherosclerosis. In conclusion, it seems that apoM plays a part in lipoprotein metabolism; however, the biological impact of apoM in humans remains to be determined.",

author = "Nielsen, {Lars B} and Christina Christoffersen and Josefin Ahnstr{\"o}m and Bj{\"o}rn Dahlb{\"a}ck",

note = "Keywords: Animals; Apolipoproteins; Atherosclerosis; Cholesterol, HDL; Gene Expression Regulation; Humans; Kidney; Mice; Models, Biological",

year = "2009",

doi = "10.1016/j.tem.2008.11.003",

language = "English",

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T1 - ApoM: gene regulation and effects on HDL metabolism

AU - Nielsen, Lars B

AU - Christoffersen, Christina

AU - Ahnström, Josefin

AU - Dahlbäck, Björn

N1 - Keywords: Animals; Apolipoproteins; Atherosclerosis; Cholesterol, HDL; Gene Expression Regulation; Humans; Kidney; Mice; Models, Biological

PY - 2009

Y1 - 2009

N2 - The recently discovered apolipoprotein M (apoM) is a plasma protein of the lipocalin family associated with the lipoproteins (mainly high-density lipoproteins, or HDLs). Expression of the apoM gene in the liver is regulated by transcription factors that control key steps in hepatic lipid and glucose metabolism. Although the concentration of plasma apoM correlates with that of cholesterol, apoM was not identified as a risk factor for cardiovascular disease in two prospective studies. In genetically modified mice, however, changes in plasma apoM concentration caused quantitative and qualitative changes in HDLs, and overexpression of the apoM gene reduced atherosclerosis. In conclusion, it seems that apoM plays a part in lipoprotein metabolism; however, the biological impact of apoM in humans remains to be determined.

AB - The recently discovered apolipoprotein M (apoM) is a plasma protein of the lipocalin family associated with the lipoproteins (mainly high-density lipoproteins, or HDLs). Expression of the apoM gene in the liver is regulated by transcription factors that control key steps in hepatic lipid and glucose metabolism. Although the concentration of plasma apoM correlates with that of cholesterol, apoM was not identified as a risk factor for cardiovascular disease in two prospective studies. In genetically modified mice, however, changes in plasma apoM concentration caused quantitative and qualitative changes in HDLs, and overexpression of the apoM gene reduced atherosclerosis. In conclusion, it seems that apoM plays a part in lipoprotein metabolism; however, the biological impact of apoM in humans remains to be determined.

U2 - 10.1016/j.tem.2008.11.003

DO - 10.1016/j.tem.2008.11.003

M3 - Journal article

C2 - 19200746

SN - 1043-2760

VL - 20

SP - 66

EP - 71

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 2

ER -

ApoM: gene regulation and effects on HDL metabolism

Abstract

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