TY - JOUR
T1 - ApoM: gene regulation and effects on HDL metabolism
AU - Nielsen, Lars B
AU - Christoffersen, Christina
AU - Ahnström, Josefin
AU - Dahlbäck, Björn
N1 - Keywords: Animals; Apolipoproteins; Atherosclerosis; Cholesterol, HDL; Gene Expression Regulation; Humans; Kidney; Mice; Models, Biological
PY - 2009
Y1 - 2009
N2 - The recently discovered apolipoprotein M (apoM) is a plasma protein of the lipocalin family associated with the lipoproteins (mainly high-density lipoproteins, or HDLs). Expression of the apoM gene in the liver is regulated by transcription factors that control key steps in hepatic lipid and glucose metabolism. Although the concentration of plasma apoM correlates with that of cholesterol, apoM was not identified as a risk factor for cardiovascular disease in two prospective studies. In genetically modified mice, however, changes in plasma apoM concentration caused quantitative and qualitative changes in HDLs, and overexpression of the apoM gene reduced atherosclerosis. In conclusion, it seems that apoM plays a part in lipoprotein metabolism; however, the biological impact of apoM in humans remains to be determined.
AB - The recently discovered apolipoprotein M (apoM) is a plasma protein of the lipocalin family associated with the lipoproteins (mainly high-density lipoproteins, or HDLs). Expression of the apoM gene in the liver is regulated by transcription factors that control key steps in hepatic lipid and glucose metabolism. Although the concentration of plasma apoM correlates with that of cholesterol, apoM was not identified as a risk factor for cardiovascular disease in two prospective studies. In genetically modified mice, however, changes in plasma apoM concentration caused quantitative and qualitative changes in HDLs, and overexpression of the apoM gene reduced atherosclerosis. In conclusion, it seems that apoM plays a part in lipoprotein metabolism; however, the biological impact of apoM in humans remains to be determined.
U2 - 10.1016/j.tem.2008.11.003
DO - 10.1016/j.tem.2008.11.003
M3 - Journal article
C2 - 19200746
SN - 1043-2760
VL - 20
SP - 66
EP - 71
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 2
ER -
