Antithyroid drug-induced fetal goitrous hypothyroidism

Sofie Bliddal; Ase Krogh Rasmussen; Karin Sundberg; Vibeke Brocks; Ulla Feldt-Rasmussen; Medscape; Sofie Bliddal; Åse Krogh Rasmussen

doi:10.1038/nrendo.2011.34

Antithyroid drug-induced fetal goitrous hypothyroidism

Sofie Bliddal, Ase Krogh Rasmussen, Karin Sundberg, Vibeke Brocks, Ulla Feldt-Rasmussen, Medscape, Sofie Bliddal, Åse Krogh Rasmussen

28 Citations (Scopus)

Abstract

Maternal overtreatment with antithyroid drugs can induce fetal goitrous hypothyroidism. This condition can have a critical effect on pregnancy outcome, as well as on fetal growth and neurological development. The purpose of this Review is to clarify if and how fetal goitrous hypothyroidism can be prevented, and how to react when prevention has failed. Understanding the importance of pregnancy-related changes in maternal thyroid status when treating a pregnant woman is crucial to preventing fetal goitrous hypothyroidism. Maternal levels of free T(4) are the most consistent indication of maternal and fetal thyroid status. In patients with fetal goitrous hypothyroidism, intra-amniotic levothyroxine injections improve fetal outcome. The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T(4) levels.

Original language	English
Journal	Nature Reviews Endocrinology
Volume	7
Issue number	7
Pages (from-to)	396-406
Number of pages	11
ISSN	1759-5029
DOIs	https://doi.org/10.1038/nrendo.2011.34
Publication status	Published - Feb 2011

Access to Document

10.1038/nrendo.2011.34

Cite this

@article{50e7d3d8ce7b4707bb9199b09e16e9e4,

title = "Antithyroid drug-induced fetal goitrous hypothyroidism",

abstract = "Maternal overtreatment with antithyroid drugs can induce fetal goitrous hypothyroidism. This condition can have a critical effect on pregnancy outcome, as well as on fetal growth and neurological development. The purpose of this Review is to clarify if and how fetal goitrous hypothyroidism can be prevented, and how to react when prevention has failed. Understanding the importance of pregnancy-related changes in maternal thyroid status when treating a pregnant woman is crucial to preventing fetal goitrous hypothyroidism. Maternal levels of free T(4) are the most consistent indication of maternal and fetal thyroid status. In patients with fetal goitrous hypothyroidism, intra-amniotic levothyroxine injections improve fetal outcome. The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T(4) levels.",

author = "Sofie Bliddal and Rasmussen, {Ase Krogh} and Karin Sundberg and Vibeke Brocks and Ulla Feldt-Rasmussen and Ulla Feldt-Rasmussen and Sofie Bliddal and Rasmussen, {{\AA}se Krogh}",

year = "2011",

month = feb,

doi = "10.1038/nrendo.2011.34",

language = "English",

volume = "7",

pages = "396--406",

journal = "Nature Reviews Endocrinology",

issn = "1759-5029",

publisher = "nature publishing group",

number = "7",

}

TY - JOUR

T1 - Antithyroid drug-induced fetal goitrous hypothyroidism

AU - Bliddal, Sofie

AU - Rasmussen, Ase Krogh

AU - Sundberg, Karin

AU - Brocks, Vibeke

AU - Feldt-Rasmussen, Ulla

AU - Medscape

AU - Bliddal, Sofie

AU - Rasmussen, Åse Krogh

PY - 2011/2

Y1 - 2011/2

N2 - Maternal overtreatment with antithyroid drugs can induce fetal goitrous hypothyroidism. This condition can have a critical effect on pregnancy outcome, as well as on fetal growth and neurological development. The purpose of this Review is to clarify if and how fetal goitrous hypothyroidism can be prevented, and how to react when prevention has failed. Understanding the importance of pregnancy-related changes in maternal thyroid status when treating a pregnant woman is crucial to preventing fetal goitrous hypothyroidism. Maternal levels of free T(4) are the most consistent indication of maternal and fetal thyroid status. In patients with fetal goitrous hypothyroidism, intra-amniotic levothyroxine injections improve fetal outcome. The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T(4) levels.

AB - Maternal overtreatment with antithyroid drugs can induce fetal goitrous hypothyroidism. This condition can have a critical effect on pregnancy outcome, as well as on fetal growth and neurological development. The purpose of this Review is to clarify if and how fetal goitrous hypothyroidism can be prevented, and how to react when prevention has failed. Understanding the importance of pregnancy-related changes in maternal thyroid status when treating a pregnant woman is crucial to preventing fetal goitrous hypothyroidism. Maternal levels of free T(4) are the most consistent indication of maternal and fetal thyroid status. In patients with fetal goitrous hypothyroidism, intra-amniotic levothyroxine injections improve fetal outcome. The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T(4) levels.

U2 - 10.1038/nrendo.2011.34

DO - 10.1038/nrendo.2011.34

M3 - Journal article

C2 - 21403664

SN - 1759-5029

VL - 7

SP - 396

EP - 406

JO - Nature Reviews Endocrinology

JF - Nature Reviews Endocrinology

IS - 7

ER -

Antithyroid drug-induced fetal goitrous hypothyroidism

Abstract

Access to Document

Fingerprint

Cite this