Antithyroid drug-induced fetal goitrous hypothyroidism

Sofie Bliddal; Ase Krogh Rasmussen; Karin Sundberg; Vibeke Brocks; Ulla Feldt-Rasmussen; Medscape; Sofie Bliddal; Åse Krogh Rasmussen

doi:10.1038/nrendo.2011.34

Antithyroid drug-induced fetal goitrous hypothyroidism

Sofie Bliddal, Ase Krogh Rasmussen, Karin Sundberg, Vibeke Brocks, Ulla Feldt-Rasmussen, Medscape, Sofie Bliddal, Åse Krogh Rasmussen

28 Citationer (Scopus)

Abstract

Maternal overtreatment with antithyroid drugs can induce fetal goitrous hypothyroidism. This condition can have a critical effect on pregnancy outcome, as well as on fetal growth and neurological development. The purpose of this Review is to clarify if and how fetal goitrous hypothyroidism can be prevented, and how to react when prevention has failed. Understanding the importance of pregnancy-related changes in maternal thyroid status when treating a pregnant woman is crucial to preventing fetal goitrous hypothyroidism. Maternal levels of free T(4) are the most consistent indication of maternal and fetal thyroid status. In patients with fetal goitrous hypothyroidism, intra-amniotic levothyroxine injections improve fetal outcome. The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T(4) levels.

Originalsprog	Engelsk
Tidsskrift	Nature Reviews Endocrinology
Vol/bind	7
Udgave nummer	7
Sider (fra-til)	396-406
Antal sider	11
ISSN	1759-5029
DOI	https://doi.org/10.1038/nrendo.2011.34
Status	Udgivet - feb. 2011

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10.1038/nrendo.2011.34

Citationsformater

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AB - Maternal overtreatment with antithyroid drugs can induce fetal goitrous hypothyroidism. This condition can have a critical effect on pregnancy outcome, as well as on fetal growth and neurological development. The purpose of this Review is to clarify if and how fetal goitrous hypothyroidism can be prevented, and how to react when prevention has failed. Understanding the importance of pregnancy-related changes in maternal thyroid status when treating a pregnant woman is crucial to preventing fetal goitrous hypothyroidism. Maternal levels of free T(4) are the most consistent indication of maternal and fetal thyroid status. In patients with fetal goitrous hypothyroidism, intra-amniotic levothyroxine injections improve fetal outcome. The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T(4) levels.

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Antithyroid drug-induced fetal goitrous hypothyroidism

Abstract

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