Anti-diabetic Xanthones from the Bark of Garcinia xanthochymus

Lien-Hoa D. Nguyen; Lien-Hoa D. Nguyen; Thi Dieu Binh Trinh; Toan B Tran; Le-Thu T Nguyen; Anna K Jäger

doi:10.1016/j.bmcl.2017.06.021

Anti-diabetic Xanthones from the Bark of Garcinia xanthochymus

Lien-Hoa D. Nguyen, Lien-Hoa D. Nguyen, Thi Dieu Binh Trinh, Toan B Tran, Le-Thu T Nguyen, Anna K Jäger

15 Citations (Scopus)

Abstract

An ethyl acetate extract the bark of Garcinia xanthochymus exhibited strong inhibition towards α-glucosidase and PTP1B with IC₅₀ values of 0.3 ± 0.1 μg/mL and 2.3 ± 0.4 μg/mL, respectively. Chemical constituents of the extract were therefore examined, and two new compounds, xanthochymusxanthones A (1) and B (2), along with ten known xanthones (3–12), were isolated. Their structures were determined using spectroscopic methods, mainly 1D and 2D NMR. Inhibitory activity of the isolated compounds was then tested, and subelliptenone F (12) showed significant effect towards α-glucosidase with IC₅₀ value of 4.1 ± 0.3 μM (compared with acarbose, IC₅₀ = 900.0 ± 3.0 μM) whilst xanthochymusxanthone B (2) exhibited remarkable activity towards PTP1B with IC₅₀ value of 8.0 ± 0.6 μM (compared with RK682, IC₅₀ = 4.4 ± 0.3 μM).

Original language	English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	27
Issue number	15
Pages (from-to)	3301-3304
ISSN	0960-894X
DOIs	https://doi.org/10.1016/j.bmcl.2017.06.021
Publication status	Published - 2017

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@article{60c483236d044ccf923c5a424b79e531,

title = "Anti-diabetic Xanthones from the Bark of Garcinia xanthochymus",

abstract = "An ethyl acetate extract the bark of Garcinia xanthochymus exhibited strong inhibition towards α-glucosidase and PTP1B with IC50 values of 0.3 ± 0.1 μg/mL and 2.3 ± 0.4 μg/mL, respectively. Chemical constituents of the extract were therefore examined, and two new compounds, xanthochymusxanthones A (1) and B (2), along with ten known xanthones (3–12), were isolated. Their structures were determined using spectroscopic methods, mainly 1D and 2D NMR. Inhibitory activity of the isolated compounds was then tested, and subelliptenone F (12) showed significant effect towards α-glucosidase with IC50 value of 4.1 ± 0.3 μM (compared with acarbose, IC50 = 900.0 ± 3.0 μM) whilst xanthochymusxanthone B (2) exhibited remarkable activity towards PTP1B with IC50 value of 8.0 ± 0.6 μM (compared with RK682, IC50 = 4.4 ± 0.3 μM).",

author = "Nguyen, {Lien-Hoa D.} and Nguyen, {Lien-Hoa D.} and Trinh, {Thi Dieu Binh} and Tran, {Toan B} and Nguyen, {Le-Thu T} and J{\"a}ger, {Anna K}",

year = "2017",

doi = "10.1016/j.bmcl.2017.06.021",

language = "English",

volume = "27",

pages = "3301--3304",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Pergamon Press",

number = "15",

}

TY - JOUR

T1 - Anti-diabetic Xanthones from the Bark of Garcinia xanthochymus

AU - Nguyen, Lien-Hoa D.

AU - Trinh, Thi Dieu Binh

AU - Tran, Toan B

AU - Nguyen, Le-Thu T

AU - Jäger, Anna K

PY - 2017

Y1 - 2017

N2 - An ethyl acetate extract the bark of Garcinia xanthochymus exhibited strong inhibition towards α-glucosidase and PTP1B with IC50 values of 0.3 ± 0.1 μg/mL and 2.3 ± 0.4 μg/mL, respectively. Chemical constituents of the extract were therefore examined, and two new compounds, xanthochymusxanthones A (1) and B (2), along with ten known xanthones (3–12), were isolated. Their structures were determined using spectroscopic methods, mainly 1D and 2D NMR. Inhibitory activity of the isolated compounds was then tested, and subelliptenone F (12) showed significant effect towards α-glucosidase with IC50 value of 4.1 ± 0.3 μM (compared with acarbose, IC50 = 900.0 ± 3.0 μM) whilst xanthochymusxanthone B (2) exhibited remarkable activity towards PTP1B with IC50 value of 8.0 ± 0.6 μM (compared with RK682, IC50 = 4.4 ± 0.3 μM).

AB - An ethyl acetate extract the bark of Garcinia xanthochymus exhibited strong inhibition towards α-glucosidase and PTP1B with IC50 values of 0.3 ± 0.1 μg/mL and 2.3 ± 0.4 μg/mL, respectively. Chemical constituents of the extract were therefore examined, and two new compounds, xanthochymusxanthones A (1) and B (2), along with ten known xanthones (3–12), were isolated. Their structures were determined using spectroscopic methods, mainly 1D and 2D NMR. Inhibitory activity of the isolated compounds was then tested, and subelliptenone F (12) showed significant effect towards α-glucosidase with IC50 value of 4.1 ± 0.3 μM (compared with acarbose, IC50 = 900.0 ± 3.0 μM) whilst xanthochymusxanthone B (2) exhibited remarkable activity towards PTP1B with IC50 value of 8.0 ± 0.6 μM (compared with RK682, IC50 = 4.4 ± 0.3 μM).

U2 - 10.1016/j.bmcl.2017.06.021

DO - 10.1016/j.bmcl.2017.06.021

M3 - Journal article

C2 - 28624142

SN - 0960-894X

VL - 27

SP - 3301

EP - 3304

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 15

ER -

Anti-diabetic Xanthones from the Bark of Garcinia xanthochymus

Abstract

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