Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs

Hassan Hamoudi; Jens-Christian Rudnick; Jan Ulrik Prause; Kerstin Tauscher; Angele Breithaupt; Jens P Teifke; Steffen Heegaard

doi:10.1111/vop.12017

Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs

Hassan Hamoudi, Jens-Christian Rudnick, Jan Ulrik Prause, Kerstin Tauscher, Angele Breithaupt, Jens P Teifke, Steffen Heegaard

Eyepath Lab

7 Citations (Scopus)

Abstract

Two sibling snow leopards, a male and a female, with bilateral anterior segment dysgenesis (ASD), are reported. Both snow leopards also had colobomas of both upper eyelids. All eyes exhibited a central corneal opacity associated with a defect in posterior corneal stroma, endothelium and Descemet's membrane. Iris strands were present attached to the termination of Descemet's membrane and to the periphery of the posterior corneal defect. The iris was hypoplastic, and cataract was present in all four eyes. The left eye of the female was microphthalmic, with no trabecular meshwork and with persistent remnant of the hyaloid artery. The male had hydrocephalus and thus some of the features of Peters' plus syndrome (Peters' anomaly in addition to systemic malformations). The histological findings in the eyes of these snow leopard siblings are identical with those described in humans with Peters' anomaly.

Original language	English
Journal	Veterinary Ophthalmology
Volume	16
Issue number	1
Pages (from-to)	130-134
Number of pages	5
ISSN	1463-5216
DOIs	https://doi.org/10.1111/vop.12017
Publication status	Published - Jul 2013

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title = "Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs",

abstract = "Two sibling snow leopards, a male and a female, with bilateral anterior segment dysgenesis (ASD), are reported. Both snow leopards also had colobomas of both upper eyelids. All eyes exhibited a central corneal opacity associated with a defect in posterior corneal stroma, endothelium and Descemet's membrane. Iris strands were present attached to the termination of Descemet's membrane and to the periphery of the posterior corneal defect. The iris was hypoplastic, and cataract was present in all four eyes. The left eye of the female was microphthalmic, with no trabecular meshwork and with persistent remnant of the hyaloid artery. The male had hydrocephalus and thus some of the features of Peters' plus syndrome (Peters' anomaly in addition to systemic malformations). The histological findings in the eyes of these snow leopard siblings are identical with those described in humans with Peters' anomaly.",

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T1 - Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs

AU - Hamoudi, Hassan

AU - Rudnick, Jens-Christian

AU - Prause, Jan Ulrik

AU - Tauscher, Kerstin

AU - Breithaupt, Angele

AU - Teifke, Jens P

AU - Heegaard, Steffen

PY - 2013/7

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N2 - Two sibling snow leopards, a male and a female, with bilateral anterior segment dysgenesis (ASD), are reported. Both snow leopards also had colobomas of both upper eyelids. All eyes exhibited a central corneal opacity associated with a defect in posterior corneal stroma, endothelium and Descemet's membrane. Iris strands were present attached to the termination of Descemet's membrane and to the periphery of the posterior corneal defect. The iris was hypoplastic, and cataract was present in all four eyes. The left eye of the female was microphthalmic, with no trabecular meshwork and with persistent remnant of the hyaloid artery. The male had hydrocephalus and thus some of the features of Peters' plus syndrome (Peters' anomaly in addition to systemic malformations). The histological findings in the eyes of these snow leopard siblings are identical with those described in humans with Peters' anomaly.

AB - Two sibling snow leopards, a male and a female, with bilateral anterior segment dysgenesis (ASD), are reported. Both snow leopards also had colobomas of both upper eyelids. All eyes exhibited a central corneal opacity associated with a defect in posterior corneal stroma, endothelium and Descemet's membrane. Iris strands were present attached to the termination of Descemet's membrane and to the periphery of the posterior corneal defect. The iris was hypoplastic, and cataract was present in all four eyes. The left eye of the female was microphthalmic, with no trabecular meshwork and with persistent remnant of the hyaloid artery. The male had hydrocephalus and thus some of the features of Peters' plus syndrome (Peters' anomaly in addition to systemic malformations). The histological findings in the eyes of these snow leopard siblings are identical with those described in humans with Peters' anomaly.

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Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs

Abstract

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