Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs

Hassan Hamoudi; Jens-Christian Rudnick; Jan Ulrik Prause; Kerstin Tauscher; Angele Breithaupt; Jens P Teifke; Steffen Heegaard

doi:10.1111/vop.12017

Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs

Hassan Hamoudi, Jens-Christian Rudnick, Jan Ulrik Prause, Kerstin Tauscher, Angele Breithaupt, Jens P Teifke, Steffen Heegaard

Eyepath Lab

7 Citationer (Scopus)

Abstract

Two sibling snow leopards, a male and a female, with bilateral anterior segment dysgenesis (ASD), are reported. Both snow leopards also had colobomas of both upper eyelids. All eyes exhibited a central corneal opacity associated with a defect in posterior corneal stroma, endothelium and Descemet's membrane. Iris strands were present attached to the termination of Descemet's membrane and to the periphery of the posterior corneal defect. The iris was hypoplastic, and cataract was present in all four eyes. The left eye of the female was microphthalmic, with no trabecular meshwork and with persistent remnant of the hyaloid artery. The male had hydrocephalus and thus some of the features of Peters' plus syndrome (Peters' anomaly in addition to systemic malformations). The histological findings in the eyes of these snow leopard siblings are identical with those described in humans with Peters' anomaly.

Originalsprog	Engelsk
Tidsskrift	Veterinary Ophthalmology
Vol/bind	16
Udgave nummer	1
Sider (fra-til)	130-134
Antal sider	5
ISSN	1463-5216
DOI	https://doi.org/10.1111/vop.12017
Status	Udgivet - jul. 2013

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10.1111/vop.12017

Citationsformater

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title = "Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs",

abstract = "Two sibling snow leopards, a male and a female, with bilateral anterior segment dysgenesis (ASD), are reported. Both snow leopards also had colobomas of both upper eyelids. All eyes exhibited a central corneal opacity associated with a defect in posterior corneal stroma, endothelium and Descemet's membrane. Iris strands were present attached to the termination of Descemet's membrane and to the periphery of the posterior corneal defect. The iris was hypoplastic, and cataract was present in all four eyes. The left eye of the female was microphthalmic, with no trabecular meshwork and with persistent remnant of the hyaloid artery. The male had hydrocephalus and thus some of the features of Peters' plus syndrome (Peters' anomaly in addition to systemic malformations). The histological findings in the eyes of these snow leopard siblings are identical with those described in humans with Peters' anomaly.",

author = "Hassan Hamoudi and Jens-Christian Rudnick and Prause, {Jan Ulrik} and Kerstin Tauscher and Angele Breithaupt and Teifke, {Jens P} and Steffen Heegaard",

note = "{\textcopyright} 2012 American College of Veterinary Ophthalmologists.",

year = "2013",

month = jul,

doi = "10.1111/vop.12017",

language = "English",

volume = "16",

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T1 - Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs

AU - Hamoudi, Hassan

AU - Rudnick, Jens-Christian

AU - Prause, Jan Ulrik

AU - Tauscher, Kerstin

AU - Breithaupt, Angele

AU - Teifke, Jens P

AU - Heegaard, Steffen

PY - 2013/7

Y1 - 2013/7

N2 - Two sibling snow leopards, a male and a female, with bilateral anterior segment dysgenesis (ASD), are reported. Both snow leopards also had colobomas of both upper eyelids. All eyes exhibited a central corneal opacity associated with a defect in posterior corneal stroma, endothelium and Descemet's membrane. Iris strands were present attached to the termination of Descemet's membrane and to the periphery of the posterior corneal defect. The iris was hypoplastic, and cataract was present in all four eyes. The left eye of the female was microphthalmic, with no trabecular meshwork and with persistent remnant of the hyaloid artery. The male had hydrocephalus and thus some of the features of Peters' plus syndrome (Peters' anomaly in addition to systemic malformations). The histological findings in the eyes of these snow leopard siblings are identical with those described in humans with Peters' anomaly.

AB - Two sibling snow leopards, a male and a female, with bilateral anterior segment dysgenesis (ASD), are reported. Both snow leopards also had colobomas of both upper eyelids. All eyes exhibited a central corneal opacity associated with a defect in posterior corneal stroma, endothelium and Descemet's membrane. Iris strands were present attached to the termination of Descemet's membrane and to the periphery of the posterior corneal defect. The iris was hypoplastic, and cataract was present in all four eyes. The left eye of the female was microphthalmic, with no trabecular meshwork and with persistent remnant of the hyaloid artery. The male had hydrocephalus and thus some of the features of Peters' plus syndrome (Peters' anomaly in addition to systemic malformations). The histological findings in the eyes of these snow leopard siblings are identical with those described in humans with Peters' anomaly.

U2 - 10.1111/vop.12017

DO - 10.1111/vop.12017

M3 - Journal article

C2 - 23217015

SN - 1463-5216

VL - 16

SP - 130

EP - 134

JO - Veterinary Ophthalmology

JF - Veterinary Ophthalmology

IS - 1

ER -

Anterior segment dysgenesis (Peters' anomaly) in two snow leopard (Panthera uncia) cubs

Abstract

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