Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

Eva Brekke; Tora Sund Morken; Anne B Walls; Helle Waagepetersen; Arne Schousboe; Ursula Sonnewald

doi:10.1007/978-3-319-45096-4_3

Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

Eva Brekke, Tora Sund Morken, Anne B Walls, Helle Waagepetersen, Arne Schousboe, Ursula Sonnewald

5 Citationer (Scopus)

Abstract

A central task of the tricarboxylic acid (TCA, Krebs, citric acid) cycle in brain is to provide precursors for biosynthesis of glutamate, GABA, aspartate and glutamine. Three of these amino acids are the partners in the intricate interaction between astrocytes and neurons and form the so-called glutamine–glutamate (GABA) cycle. The ketoacids α-ketoglutarate and oxaloacetate are removed from the cycle for this process. When something is removed from the TCA cycle it must be replaced to permit the continued function of this essential pathway, a process termed anaplerosis. This anaplerotic process in the brain is mainly carried out by pyruvate carboxylation performed by pyruvate carboxylase. The present book chapter gives an introduction and overview into this carboxylation and additionally anaplerosis mediated by propionyl-CoA carboxylase under physiological conditions in the adult and in the developing rodent brain. Furthermore, examples are given about pathological conditions in which anaplerosis is disturbed.

Originalsprog	Engelsk
Titel	The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis
Antal sider	16
Vol/bind	13
Forlag	Springer
Publikationsdato	2016
Sider	43-58
Kapitel	3
ISBN (Elektronisk)	978-3-319-45096-4
DOI	https://doi.org/10.1007/978-3-319-45096-4_3
Status	Udgivet - 2016

Navn	Advances in Neurobiology
Vol/bind	13
ISSN	2190-5215

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10.1007/978-3-319-45096-4_3

Citationsformater

Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. / Brekke, Eva; Morken, Tora Sund; Walls, Anne B et al.
The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Bind 13 Springer, 2016. s. 43-58 (Advances in Neurobiology, Bind 13).

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

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AU - Schousboe, Arne

AU - Sonnewald, Ursula

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Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

Abstract

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