Anaplastic thyroid carcinoma in Denmark 1996-2012: A national prospective study of 219 patients

Gitte Bjørn Hvilsom; Stefano Christian Londero; Christoffer Holst Hahn; Sten Schytte; Henrik Baymler Pedersen; Peer Christiansen; Katalin Kiss; Stine Rosenkilde Larsen; Marie Louise Jespersen; Giedrius Lelkaitis; Christian Godballe

doi:10.1016/j.canep.2018.01.011

Anaplastic thyroid carcinoma in Denmark 1996-2012: A national prospective study of 219 patients

Gitte Bjørn Hvilsom, Stefano Christian Londero, Christoffer Holst Hahn, Sten Schytte, Henrik Baymler Pedersen, Peer Christiansen, Katalin Kiss, Stine Rosenkilde Larsen, Marie Louise Jespersen, Giedrius Lelkaitis, Christian Godballe

Department of Clinical Medicine

7 Citations (Scopus)

Abstract

BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.

METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014.

RESULTS: We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56% of the patients had lymph node metastasis and 38% distant metastasis. We observed one- and five-year survival of 20.7% and 11.0%, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold.

CONCLUSION: As new information, our study adds "respiratory impairment at diagnosis" and "introduction of a national fast track cancer program" to the list of already established prognostic indicators for ATC.

Original language	English
Journal	Cancer Epidemiology
Volume	53
Pages (from-to)	65-71
Number of pages	7
ISSN	1877-7821
DOIs	https://doi.org/10.1016/j.canep.2018.01.011
Publication status	Published - Apr 2018

Keywords

Adult
Aged
Aged, 80 and over
Cohort Studies
Databases, Factual
Denmark/epidemiology
Female
Humans
Incidence
Lymphatic Metastasis/pathology
Male
Middle Aged
Multivariate Analysis
Prognosis
Prospective Studies
Thyroid Carcinoma, Anaplastic/epidemiology
Thyroid Neoplasms/epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canep.2018.01.011

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title = "Anaplastic thyroid carcinoma in Denmark 1996-2012: A national prospective study of 219 patients",

abstract = "BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014.RESULTS: We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56% of the patients had lymph node metastasis and 38% distant metastasis. We observed one- and five-year survival of 20.7% and 11.0%, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold.CONCLUSION: As new information, our study adds {"}respiratory impairment at diagnosis{"} and {"}introduction of a national fast track cancer program{"} to the list of already established prognostic indicators for ATC.",

keywords = "Adult, Aged, Aged, 80 and over, Cohort Studies, Databases, Factual, Denmark/epidemiology, Female, Humans, Incidence, Lymphatic Metastasis/pathology, Male, Middle Aged, Multivariate Analysis, Prognosis, Prospective Studies, Thyroid Carcinoma, Anaplastic/epidemiology, Thyroid Neoplasms/epidemiology",

author = "Hvilsom, {Gitte Bj{\o}rn} and Londero, {Stefano Christian} and Hahn, {Christoffer Holst} and Sten Schytte and Pedersen, {Henrik Baymler} and Peer Christiansen and Katalin Kiss and Larsen, {Stine Rosenkilde} and Jespersen, {Marie Louise} and Giedrius Lelkaitis and Christian Godballe",

year = "2018",

month = apr,

doi = "10.1016/j.canep.2018.01.011",

language = "English",

volume = "53",

pages = "65--71",

journal = "Cancer Epidemiology",

issn = "1877-7821",

publisher = "Elsevier",

}

TY - JOUR

T1 - Anaplastic thyroid carcinoma in Denmark 1996-2012

T2 - A national prospective study of 219 patients

AU - Hvilsom, Gitte Bjørn

AU - Londero, Stefano Christian

AU - Hahn, Christoffer Holst

AU - Schytte, Sten

AU - Pedersen, Henrik Baymler

AU - Christiansen, Peer

AU - Kiss, Katalin

AU - Larsen, Stine Rosenkilde

AU - Jespersen, Marie Louise

AU - Lelkaitis, Giedrius

AU - Godballe, Christian

PY - 2018/4

Y1 - 2018/4

N2 - BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014.RESULTS: We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56% of the patients had lymph node metastasis and 38% distant metastasis. We observed one- and five-year survival of 20.7% and 11.0%, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold.CONCLUSION: As new information, our study adds "respiratory impairment at diagnosis" and "introduction of a national fast track cancer program" to the list of already established prognostic indicators for ATC.

AB - BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014.RESULTS: We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56% of the patients had lymph node metastasis and 38% distant metastasis. We observed one- and five-year survival of 20.7% and 11.0%, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold.CONCLUSION: As new information, our study adds "respiratory impairment at diagnosis" and "introduction of a national fast track cancer program" to the list of already established prognostic indicators for ATC.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Cohort Studies

KW - Databases, Factual

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Lymphatic Metastasis/pathology

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Prognosis

KW - Prospective Studies

KW - Thyroid Carcinoma, Anaplastic/epidemiology

KW - Thyroid Neoplasms/epidemiology

U2 - 10.1016/j.canep.2018.01.011

DO - 10.1016/j.canep.2018.01.011

M3 - Journal article

C2 - 29414634

SN - 1877-7821

VL - 53

SP - 65

EP - 71

JO - Cancer Epidemiology

JF - Cancer Epidemiology

ER -

Anaplastic thyroid carcinoma in Denmark 1996-2012: A national prospective study of 219 patients

Abstract

Keywords

UN SDGs

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