TY - JOUR
T1 - Anaplastic thyroid carcinoma in Denmark 1996-2012
T2 - A national prospective study of 219 patients
AU - Hvilsom, Gitte Bjørn
AU - Londero, Stefano Christian
AU - Hahn, Christoffer Holst
AU - Schytte, Sten
AU - Pedersen, Henrik Baymler
AU - Christiansen, Peer
AU - Kiss, Katalin
AU - Larsen, Stine Rosenkilde
AU - Jespersen, Marie Louise
AU - Lelkaitis, Giedrius
AU - Godballe, Christian
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018/4
Y1 - 2018/4
N2 - BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014.RESULTS: We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56% of the patients had lymph node metastasis and 38% distant metastasis. We observed one- and five-year survival of 20.7% and 11.0%, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold.CONCLUSION: As new information, our study adds "respiratory impairment at diagnosis" and "introduction of a national fast track cancer program" to the list of already established prognostic indicators for ATC.
AB - BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients.METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014.RESULTS: We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56% of the patients had lymph node metastasis and 38% distant metastasis. We observed one- and five-year survival of 20.7% and 11.0%, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold.CONCLUSION: As new information, our study adds "respiratory impairment at diagnosis" and "introduction of a national fast track cancer program" to the list of already established prognostic indicators for ATC.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Cohort Studies
KW - Databases, Factual
KW - Denmark/epidemiology
KW - Female
KW - Humans
KW - Incidence
KW - Lymphatic Metastasis/pathology
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Prognosis
KW - Prospective Studies
KW - Thyroid Carcinoma, Anaplastic/epidemiology
KW - Thyroid Neoplasms/epidemiology
U2 - 10.1016/j.canep.2018.01.011
DO - 10.1016/j.canep.2018.01.011
M3 - Journal article
C2 - 29414634
SN - 1877-7821
VL - 53
SP - 65
EP - 71
JO - Cancer Epidemiology
JF - Cancer Epidemiology
ER -
