Analysis of protein aggregation in neurodegenerative disease

Jeppe Trudslev Pedersen; Niels H.H. Heegaard

doi:10.1021/ac400023c

Analysis of protein aggregation in neurodegenerative disease

Jeppe Trudslev Pedersen, Niels H.H. Heegaard

Department of Chemistry

49 Citations (Scopus)

Abstract

Pathological protein and peptide aggregation are key events in a number of chronic and devastating neurodegenerative conditions including dementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous system diseases such as Parkinson's and Huntington's disease and amyotrophic lateral sclerosis. Analytical methods for studying protein aggregation in these diseases are important for mapping pathophysiological events and ultimately for the development of new therapies and better diagnostic tools.

Original language	English
Journal	Analytical Chemistry
Volume	85
Issue number	9
Pages (from-to)	4215-4227
Number of pages	13
ISSN	0003-2700
DOIs	https://doi.org/10.1021/ac400023c
Publication status	Published - 7 May 2013

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abstract = "Pathological protein and peptide aggregation are key events in a number of chronic and devastating neurodegenerative conditions including dementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous system diseases such as Parkinson's and Huntington's disease and amyotrophic lateral sclerosis. Analytical methods for studying protein aggregation in these diseases are important for mapping pathophysiological events and ultimately for the development of new therapies and better diagnostic tools.",

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AB - Pathological protein and peptide aggregation are key events in a number of chronic and devastating neurodegenerative conditions including dementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous system diseases such as Parkinson's and Huntington's disease and amyotrophic lateral sclerosis. Analytical methods for studying protein aggregation in these diseases are important for mapping pathophysiological events and ultimately for the development of new therapies and better diagnostic tools.

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JO - Industrial And Engineering Chemistry Analytical Edition

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Analysis of protein aggregation in neurodegenerative disease

Abstract

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