Analysis of protein aggregation in neurodegenerative disease

Jeppe Trudslev Pedersen; Niels H.H. Heegaard

doi:10.1021/ac400023c

Analysis of protein aggregation in neurodegenerative disease

Jeppe Trudslev Pedersen, Niels H.H. Heegaard

Kemisk Institut

49 Citationer (Scopus)

Abstract

Pathological protein and peptide aggregation are key events in a number of chronic and devastating neurodegenerative conditions including dementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous system diseases such as Parkinson's and Huntington's disease and amyotrophic lateral sclerosis. Analytical methods for studying protein aggregation in these diseases are important for mapping pathophysiological events and ultimately for the development of new therapies and better diagnostic tools.

Originalsprog	Engelsk
Tidsskrift	Analytical Chemistry
Vol/bind	85
Udgave nummer	9
Sider (fra-til)	4215-4227
Antal sider	13
ISSN	0003-2700
DOI	https://doi.org/10.1021/ac400023c
Status	Udgivet - 7 maj 2013

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10.1021/ac400023c

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abstract = "Pathological protein and peptide aggregation are key events in a number of chronic and devastating neurodegenerative conditions including dementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous system diseases such as Parkinson's and Huntington's disease and amyotrophic lateral sclerosis. Analytical methods for studying protein aggregation in these diseases are important for mapping pathophysiological events and ultimately for the development of new therapies and better diagnostic tools.",

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AU - Pedersen, Jeppe Trudslev

AU - Heegaard, Niels H.H.

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N2 - Pathological protein and peptide aggregation are key events in a number of chronic and devastating neurodegenerative conditions including dementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous system diseases such as Parkinson's and Huntington's disease and amyotrophic lateral sclerosis. Analytical methods for studying protein aggregation in these diseases are important for mapping pathophysiological events and ultimately for the development of new therapies and better diagnostic tools.

AB - Pathological protein and peptide aggregation are key events in a number of chronic and devastating neurodegenerative conditions including dementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous system diseases such as Parkinson's and Huntington's disease and amyotrophic lateral sclerosis. Analytical methods for studying protein aggregation in these diseases are important for mapping pathophysiological events and ultimately for the development of new therapies and better diagnostic tools.

U2 - 10.1021/ac400023c

DO - 10.1021/ac400023c

M3 - Journal article

C2 - 23472885

SN - 0003-2700

VL - 85

SP - 4215

EP - 4227

JO - Industrial And Engineering Chemistry Analytical Edition

JF - Industrial And Engineering Chemistry Analytical Edition

IS - 9

ER -

Analysis of protein aggregation in neurodegenerative disease

Abstract

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