TY - JOUR
T1 - An update on head and neck cancer
T2 - new entities and their histopathology, molecular background, treatment, and outcome
AU - Andreasen, Simon
AU - Kiss, Katalin
AU - Mikkelsen, Lauge Hjorth
AU - Channir, Hani Ibrahim
AU - Plaschke, Christina Caroline
AU - Melchior, Linea Cecilie
AU - Eriksen, Jesper Grau
AU - Wessel, Irene
N1 - © 2019 APMIS. Published by John Wiley & Sons Ltd.
PY - 2019/5
Y1 - 2019/5
N2 - The head and neck region harbor numerous specialized tissues of all lineages giving rise to a plethora of different malignancies. In recent years, new types and subtypes of cancer has been described here due to the recognition of their histological and molecular characteristics. Some have been formally accepted in the most recent classifications from the World Health Organization (WHO) and American Joint Committee on Cancer (AJCC) as distinct diseases due to characteristics in clinical presentation, outcome, and treatment. In particular, this applies to malignancies of the salivary gland, sinonasal tract, and oropharynx. In this overview, we present the most recent developments in the classification, histopathological characteristics, and molecular features of head and neck cancer. The clinical and radiological characteristics, outcome, and treatment options including perspectives for targeted therapies, are discussed.
AB - The head and neck region harbor numerous specialized tissues of all lineages giving rise to a plethora of different malignancies. In recent years, new types and subtypes of cancer has been described here due to the recognition of their histological and molecular characteristics. Some have been formally accepted in the most recent classifications from the World Health Organization (WHO) and American Joint Committee on Cancer (AJCC) as distinct diseases due to characteristics in clinical presentation, outcome, and treatment. In particular, this applies to malignancies of the salivary gland, sinonasal tract, and oropharynx. In this overview, we present the most recent developments in the classification, histopathological characteristics, and molecular features of head and neck cancer. The clinical and radiological characteristics, outcome, and treatment options including perspectives for targeted therapies, are discussed.
U2 - 10.1111/apm.12901
DO - 10.1111/apm.12901
M3 - Review
C2 - 30811708
SN - 0903-4641
JO - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
ER -
