An update on head and neck cancer: new entities and their histopathology, molecular background, treatment, and outcome

TY - JOUR

T1 - An update on head and neck cancer

T2 - new entities and their histopathology, molecular background, treatment, and outcome

AU - Andreasen, Simon

AU - Kiss, Katalin

AU - Mikkelsen, Lauge Hjorth

AU - Channir, Hani Ibrahim

AU - Plaschke, Christina Caroline

AU - Melchior, Linea Cecilie

AU - Eriksen, Jesper Grau

AU - Wessel, Irene

N1 - © 2019 APMIS. Published by John Wiley & Sons Ltd.

PY - 2019/5

Y1 - 2019/5

N2 - The head and neck region harbor numerous specialized tissues of all lineages giving rise to a plethora of different malignancies. In recent years, new types and subtypes of cancer has been described here due to the recognition of their histological and molecular characteristics. Some have been formally accepted in the most recent classifications from the World Health Organization (WHO) and American Joint Committee on Cancer (AJCC) as distinct diseases due to characteristics in clinical presentation, outcome, and treatment. In particular, this applies to malignancies of the salivary gland, sinonasal tract, and oropharynx. In this overview, we present the most recent developments in the classification, histopathological characteristics, and molecular features of head and neck cancer. The clinical and radiological characteristics, outcome, and treatment options including perspectives for targeted therapies, are discussed.

AB - The head and neck region harbor numerous specialized tissues of all lineages giving rise to a plethora of different malignancies. In recent years, new types and subtypes of cancer has been described here due to the recognition of their histological and molecular characteristics. Some have been formally accepted in the most recent classifications from the World Health Organization (WHO) and American Joint Committee on Cancer (AJCC) as distinct diseases due to characteristics in clinical presentation, outcome, and treatment. In particular, this applies to malignancies of the salivary gland, sinonasal tract, and oropharynx. In this overview, we present the most recent developments in the classification, histopathological characteristics, and molecular features of head and neck cancer. The clinical and radiological characteristics, outcome, and treatment options including perspectives for targeted therapies, are discussed.

U2 - 10.1111/apm.12901

DO - 10.1111/apm.12901

M3 - Review

C2 - 30811708

SN - 0903-465X

JO - APMIS. Supplementum

JF - APMIS. Supplementum

ER -