An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer

Jonas Stenløkke Madsen; Ole Hylling; Samuel Jehan Auguste Jacquiod; Sophia Pécastaings; Lars H. Hansen; Leise Riber; Gisle Alberg Vestergaard; Søren Johannes Sørensen

doi:10.1038/s41396-018-0183-0

An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer

Jonas Stenløkke Madsen, Ole Hylling, Samuel Jehan Auguste Jacquiod, Sophia Pécastaings, Lars H. Hansen, Leise Riber, Gisle Alberg Vestergaard, Søren Johannes Sørensen^*

^*Corresponding author for this work

10 Citations (Scopus)

Abstract

The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.

Original language	English
Journal	ISME Journal
Volume	12
Issue number	9
Pages (from-to)	2330-2334
Number of pages	5
ISSN	1751-7362
DOIs	https://doi.org/10.1038/s41396-018-0183-0
Publication status	Published - 1 Sept 2018

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title = "An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer",

abstract = "The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.",

author = "Madsen, {Jonas Stenl{\o}kke} and Ole Hylling and Jacquiod, {Samuel Jehan Auguste} and Sophia P{\'e}castaings and Hansen, {Lars H.} and Leise Riber and Vestergaard, {Gisle Alberg} and S{\o}rensen, {S{\o}ren Johannes}",

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T1 - An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer

AU - Madsen, Jonas Stenløkke

AU - Hylling, Ole

AU - Jacquiod, Samuel Jehan Auguste

AU - Pécastaings, Sophia

AU - Hansen, Lars H.

AU - Riber, Leise

AU - Vestergaard, Gisle Alberg

AU - Sørensen, Søren Johannes

PY - 2018/9/1

Y1 - 2018/9/1

N2 - The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.

AB - The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.

U2 - 10.1038/s41396-018-0183-0

DO - 10.1038/s41396-018-0183-0

M3 - Journal article

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AN - SCOPUS:85048481780

SN - 1751-7362

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SP - 2330

EP - 2334

JO - I S M E Journal

JF - I S M E Journal

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ER -

An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer

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