An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer

Jonas Stenløkke Madsen; Ole Hylling; Samuel Jehan Auguste Jacquiod; Sophia Pécastaings; Lars H. Hansen; Leise Riber; Gisle Alberg Vestergaard; Søren Johannes Sørensen

doi:10.1038/s41396-018-0183-0

An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer

Jonas Stenløkke Madsen, Ole Hylling, Samuel Jehan Auguste Jacquiod, Sophia Pécastaings, Lars H. Hansen, Leise Riber, Gisle Alberg Vestergaard, Søren Johannes Sørensen^*

^*Corresponding author af dette arbejde

10 Citationer (Scopus)

Abstract

The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.

Originalsprog	Engelsk
Tidsskrift	ISME Journal
Vol/bind	12
Udgave nummer	9
Sider (fra-til)	2330-2334
Antal sider	5
ISSN	1751-7362
DOI	https://doi.org/10.1038/s41396-018-0183-0
Status	Udgivet - 1 sep. 2018

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abstract = "The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.",

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T1 - An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer

AU - Madsen, Jonas Stenløkke

AU - Hylling, Ole

AU - Jacquiod, Samuel Jehan Auguste

AU - Pécastaings, Sophia

AU - Hansen, Lars H.

AU - Riber, Leise

AU - Vestergaard, Gisle Alberg

AU - Sørensen, Søren Johannes

PY - 2018/9/1

Y1 - 2018/9/1

N2 - The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.

AB - The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.

U2 - 10.1038/s41396-018-0183-0

DO - 10.1038/s41396-018-0183-0

M3 - Journal article

C2 - 29899518

AN - SCOPUS:85048481780

SN - 1751-7362

VL - 12

SP - 2330

EP - 2334

JO - ISME Journal

JF - ISME Journal

IS - 9

ER -

An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer

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