An association study between the norepinephrine transporter gene and depression

Henriette Nørmølle Buttenschøn; Iben Søgaard Jacobsen; Matias B Grynderup; Åse Marie Hansen; Henrik A. Kolstad; Linda Kaerlev; Jane F Thomsen; Merete Nordentoft; Asli Silahtaroglu; Niels Tommerup; Zeynep Tümer; Jesper Krogh; Anders Børglum; Ole Mors

doi:10.1097/ypg.0000000000000003

An association study between the norepinephrine transporter gene and depression

Henriette Nørmølle Buttenschøn, Iben Søgaard Jacobsen, Matias B Grynderup, Åse Marie Hansen, Henrik A. Kolstad, Linda Kaerlev, Jane F Thomsen, Merete Nordentoft, Asli Silahtaroglu, Niels Tommerup, Zeynep Tümer, Jesper Krogh, Anders Børglum, Ole Mors

3 Citations (Scopus)

Abstract

A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.

Original language	English
Journal	Psychiatric Genetics
Volume	23
Issue number	5
Pages (from-to)	217-21
Number of pages	5
ISSN	0955-8829
DOIs	https://doi.org/10.1097/ypg.0000000000000003
Publication status	Published - Oct 2013

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Buttenschøn, H. N., Jacobsen, I. S., Grynderup, M. B., Hansen, Å. M., Kolstad, H. A., Kaerlev, L., Thomsen, J. F., Nordentoft, M., Silahtaroglu, A., Tommerup, N., Tümer, Z., Krogh, J., Børglum, A., & Mors, O. (2013). An association study between the norepinephrine transporter gene and depression. Psychiatric Genetics, 23(5), 217-21. https://doi.org/10.1097/ypg.0000000000000003

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abstract = "A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.",

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T1 - An association study between the norepinephrine transporter gene and depression

AU - Buttenschøn, Henriette Nørmølle

AU - Jacobsen, Iben Søgaard

AU - Grynderup, Matias B

AU - Hansen, Åse Marie

AU - Kolstad, Henrik A.

AU - Kaerlev, Linda

AU - Thomsen, Jane F

AU - Nordentoft, Merete

AU - Silahtaroglu, Asli

AU - Tommerup, Niels

AU - Tümer, Zeynep

AU - Krogh, Jesper

AU - Børglum, Anders

AU - Mors, Ole

PY - 2013/10

Y1 - 2013/10

N2 - A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.

AB - A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.

U2 - 10.1097/ypg.0000000000000003

DO - 10.1097/ypg.0000000000000003

M3 - Journal article

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SN - 0955-8829

VL - 23

SP - 217

EP - 221

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 5

ER -

An association study between the norepinephrine transporter gene and depression

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