Allelic drop-out probabilities estimated by logistic regression--Further considerations and practical implementation

TY - JOUR

T1 - Allelic drop-out probabilities estimated by logistic regression--Further considerations and practical implementation

AU - Tvedebrink, Torben

AU - Eriksen, Poul Svante

AU - Asplund, Maria

AU - Mogensen, Helle Smidt

AU - Morling, Niels

PY - 2012/3

Y1 - 2012/3

N2 - Abstract: We discuss the model for estimating drop-out probabilities presented by Tvedebrink et al. [7] and the concerns, that have been raised. The criticism of the model has demonstrated that the model is not perfect. However, the model is very useful for advanced forensic genetic work, where allelic drop-out is occurring. With this discussion, we hope to improve the drop-out model, so that it can be used for practical forensic genetics and stimulate further discussions. We discuss how to estimate drop-out probabilities when using a varying number of PCR cycles and other experimental conditions.

AB - Abstract: We discuss the model for estimating drop-out probabilities presented by Tvedebrink et al. [7] and the concerns, that have been raised. The criticism of the model has demonstrated that the model is not perfect. However, the model is very useful for advanced forensic genetic work, where allelic drop-out is occurring. With this discussion, we hope to improve the drop-out model, so that it can be used for practical forensic genetics and stimulate further discussions. We discuss how to estimate drop-out probabilities when using a varying number of PCR cycles and other experimental conditions.

KW - Forensic genetics

U2 - 10.1016/j.fsigen.2011.06.004

DO - 10.1016/j.fsigen.2011.06.004

M3 - Journal article

SN - 1872-4973

VL - 6

SP - 263

EP - 267

JO - Forensic Science International: Genetics

JF - Forensic Science International: Genetics

IS - 2

ER -