Alkamides from Phyllanthus fraternus

A A Sittie; E Lemmich; C E Olsen; L Hviid; S Brøgger Christensen

Alkamides from Phyllanthus fraternus

A A Sittie, E Lemmich, C E Olsen, L Hviid, S Brøgger Christensen

31 Citations (Scopus)

Abstract

Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.

Original language	English
Journal	Planta Medica
Volume	64
Issue number	2
Pages (from-to)	192-3
Number of pages	1
ISSN	0032-0943
Publication status	Published - 1998

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title = "Alkamides from Phyllanthus fraternus",

abstract = "Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.",

author = "Sittie, {A A} and E Lemmich and Olsen, {C E} and L Hviid and {Br{\o}gger Christensen}, S",

note = "Keywords: Amides; Animals; Antiprotozoal Agents; Humans; Leishmania major; Lymphocyte Activation; Lymphocytes; Plants, Medicinal; Plasmodium falciparum",

year = "1998",

language = "English",

volume = "64",

pages = "192--3",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "GeorgThieme Verlag",

number = "2",

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TY - JOUR

T1 - Alkamides from Phyllanthus fraternus

AU - Sittie, A A

AU - Lemmich, E

AU - Olsen, C E

AU - Hviid, L

AU - Brøgger Christensen, S

N1 - Keywords: Amides; Animals; Antiprotozoal Agents; Humans; Leishmania major; Lymphocyte Activation; Lymphocytes; Plants, Medicinal; Plasmodium falciparum

PY - 1998

Y1 - 1998

N2 - Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.

AB - Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.

M3 - Journal article

C2 - 9525113

SN - 0032-0943

VL - 64

SP - 192

EP - 193

JO - Planta Medica

JF - Planta Medica

IS - 2

ER -

Alkamides from Phyllanthus fraternus

Abstract

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