Age-related decline in mitral peak diastolic velocities is unaffected in well-trained runners

TY - JOUR

T1 - Age-related decline in mitral peak diastolic velocities is unaffected in well-trained runners

AU - Olsen, Rasmus Huan

AU - Couppé, Christian

AU - Dall, Christian Have

AU - Monk-Hansen, Tea

AU - Mikkelsen, Ulla Ramer

AU - Karlsen, Anders

AU - Høst, Nis Baun

AU - Magnusson, S Peter

AU - Prescott, Eva

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objectives. We examined whether diastolic left ventricular function in young and senior lifelong endurance runners was significantly different from that in sedentary age-matched controls, and whether lifelong endurance running appears to modify the age-related decline in diastolic left ventricular function. Design. The study comprised 17 senior athletes (age: 59-75 years, running distance: 30-70 km/week), 10 young athletes (age: 20-36 years, matched for running distance), and 11 senior and 12 young weight-matched sedentary controls. Peak early (E) and late (A) mitral inflow and early (e') and late (a') diastolic and systolic (s') annular longitudinal tissue Doppler velocities were measured by echocardiography during four stages (rest, supine bike exercise at 30% and 60% of maximal workload, and recovery). Results. The athletes had marked cardiac remodeling, while overall differences in mitral inflow and annular tissue Doppler velocities during rest and exercise were more associated with age than with training status. The senior participants had lower E/A at rest, overall lower E, e' and s', and greater E/e' compared to the young participants (all values of P < 0.05). The athletes had greater E/A (P = 0.004), but tissue Doppler velocities were not different from those of the controls. Conclusions. Lifelong endurance running was not found to be associated with major attenuation of the age-related decline in diastolic function at rest or during exercise.

AB - Objectives. We examined whether diastolic left ventricular function in young and senior lifelong endurance runners was significantly different from that in sedentary age-matched controls, and whether lifelong endurance running appears to modify the age-related decline in diastolic left ventricular function. Design. The study comprised 17 senior athletes (age: 59-75 years, running distance: 30-70 km/week), 10 young athletes (age: 20-36 years, matched for running distance), and 11 senior and 12 young weight-matched sedentary controls. Peak early (E) and late (A) mitral inflow and early (e') and late (a') diastolic and systolic (s') annular longitudinal tissue Doppler velocities were measured by echocardiography during four stages (rest, supine bike exercise at 30% and 60% of maximal workload, and recovery). Results. The athletes had marked cardiac remodeling, while overall differences in mitral inflow and annular tissue Doppler velocities during rest and exercise were more associated with age than with training status. The senior participants had lower E/A at rest, overall lower E, e' and s', and greater E/e' compared to the young participants (all values of P < 0.05). The athletes had greater E/A (P = 0.004), but tissue Doppler velocities were not different from those of the controls. Conclusions. Lifelong endurance running was not found to be associated with major attenuation of the age-related decline in diastolic function at rest or during exercise.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aging

KW - Bicycling

KW - Case-Control Studies

KW - Cross-Sectional Studies

KW - Diastole

KW - Echocardiography, Doppler

KW - Exercise Test

KW - Humans

KW - Male

KW - Middle Aged

KW - Mitral Valve

KW - Physical Endurance

KW - Running

KW - Ventricular Function, Left

KW - Young Adult

U2 - 10.3109/14017431.2015.1049654

DO - 10.3109/14017431.2015.1049654

M3 - Journal article

C2 - 25968969

SN - 1401-7431

VL - 49

SP - 183

EP - 192

JO - Scandinavian Cardiovascular Journal

JF - Scandinavian Cardiovascular Journal

IS - 4

ER -