Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)

Anne Kirstine Havnsøe Krogh; Jo F. H. Lundsgaard; Jaco Bakker; Jan A. M. Langermans; Frank A. W. Verreck; Mads Kjelgaard-Hansen; Stine Jacobsen; Mads Frost Bertelsen

doi:10.1638/2013-0153R.1

Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)

Anne Kirstine Havnsøe Krogh, Jo F. H. Lundsgaard, Jaco Bakker, Jan A. M. Langermans, Frank A. W. Verreck, Mads Kjelgaard-Hansen, Stine Jacobsen, Mads Frost Bertelsen

Food Safety and Zoonoses

6 Citations (Scopus)

Abstract

Five acute-phase reactants-serum amyloid A (SAA), C-reactive protein (CRP), haptoglobin, albumin, and iron-were measured using commercially available assays in 110 healthy rhesus macaques (Macaca mulatta), and reference intervals were established for future use in health monitoring of this species. Reference intervals established were as follows: SAA, 29.5-87.7 mg/L; CRP, 0-17.5 mg/L; haptoglobin, 354.3-2,414.7 mg/L; albumin, 36.1-53.0 g/L; and iron, 13.3-40.2 μmol/L. Furthermore, changes in the acute-phase reactants were studied in two additional groups of animals: eight rhesus macaques suffering from acute traumatic injuries and nine rhesus macaques experimentally infected with Mycobacterium tuberculosis reflecting a chronic active inflammation. In animals with inflammation, SAA and haptoglobin concentrations were moderately increased, while CRP increased more than 200-fold. In addition, marked decreases in albumin and iron concentrations were observed. These results show that SAA, CRP, and haptoglobin are positive acute-phase proteins, whereas albumin and iron are negative acute-phase reactants in rhesus macaques.

Original language	English
Journal	Journal of Zoo and Wildlife Medicine
Volume	45
Issue number	2
Pages (from-to)	306-314
Number of pages	9
ISSN	1042-7260
DOIs	https://doi.org/10.1638/2013-0153R.1
Publication status	Published - Jun 2014

Keywords

Faculty of Health and Medical Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1638/2013-0153R.1

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title = "Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)",

abstract = "Five acute-phase reactants-serum amyloid A (SAA), C-reactive protein (CRP), haptoglobin, albumin, and iron-were measured using commercially available assays in 110 healthy rhesus macaques (Macaca mulatta), and reference intervals were established for future use in health monitoring of this species. Reference intervals established were as follows: SAA, 29.5-87.7 mg/L; CRP, 0-17.5 mg/L; haptoglobin, 354.3-2,414.7 mg/L; albumin, 36.1-53.0 g/L; and iron, 13.3-40.2 μmol/L. Furthermore, changes in the acute-phase reactants were studied in two additional groups of animals: eight rhesus macaques suffering from acute traumatic injuries and nine rhesus macaques experimentally infected with Mycobacterium tuberculosis reflecting a chronic active inflammation. In animals with inflammation, SAA and haptoglobin concentrations were moderately increased, while CRP increased more than 200-fold. In addition, marked decreases in albumin and iron concentrations were observed. These results show that SAA, CRP, and haptoglobin are positive acute-phase proteins, whereas albumin and iron are negative acute-phase reactants in rhesus macaques.",

keywords = "Faculty of Health and Medical Sciences, Primates, Inflammation, Acute phase proteins, Veterinary medicine",

author = "Krogh, {Anne Kirstine Havns{\o}e} and Lundsgaard, {Jo F. H.} and Jaco Bakker and Langermans, {Jan A. M.} and Verreck, {Frank A. W.} and Mads Kjelgaard-Hansen and Stine Jacobsen and Bertelsen, {Mads Frost}",

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language = "English",

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T1 - Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)

AU - Krogh, Anne Kirstine Havnsøe

AU - Lundsgaard, Jo F. H.

AU - Bakker, Jaco

AU - Langermans, Jan A. M.

AU - Verreck, Frank A. W.

AU - Kjelgaard-Hansen, Mads

AU - Jacobsen, Stine

AU - Bertelsen, Mads Frost

PY - 2014/6

Y1 - 2014/6

N2 - Five acute-phase reactants-serum amyloid A (SAA), C-reactive protein (CRP), haptoglobin, albumin, and iron-were measured using commercially available assays in 110 healthy rhesus macaques (Macaca mulatta), and reference intervals were established for future use in health monitoring of this species. Reference intervals established were as follows: SAA, 29.5-87.7 mg/L; CRP, 0-17.5 mg/L; haptoglobin, 354.3-2,414.7 mg/L; albumin, 36.1-53.0 g/L; and iron, 13.3-40.2 μmol/L. Furthermore, changes in the acute-phase reactants were studied in two additional groups of animals: eight rhesus macaques suffering from acute traumatic injuries and nine rhesus macaques experimentally infected with Mycobacterium tuberculosis reflecting a chronic active inflammation. In animals with inflammation, SAA and haptoglobin concentrations were moderately increased, while CRP increased more than 200-fold. In addition, marked decreases in albumin and iron concentrations were observed. These results show that SAA, CRP, and haptoglobin are positive acute-phase proteins, whereas albumin and iron are negative acute-phase reactants in rhesus macaques.

AB - Five acute-phase reactants-serum amyloid A (SAA), C-reactive protein (CRP), haptoglobin, albumin, and iron-were measured using commercially available assays in 110 healthy rhesus macaques (Macaca mulatta), and reference intervals were established for future use in health monitoring of this species. Reference intervals established were as follows: SAA, 29.5-87.7 mg/L; CRP, 0-17.5 mg/L; haptoglobin, 354.3-2,414.7 mg/L; albumin, 36.1-53.0 g/L; and iron, 13.3-40.2 μmol/L. Furthermore, changes in the acute-phase reactants were studied in two additional groups of animals: eight rhesus macaques suffering from acute traumatic injuries and nine rhesus macaques experimentally infected with Mycobacterium tuberculosis reflecting a chronic active inflammation. In animals with inflammation, SAA and haptoglobin concentrations were moderately increased, while CRP increased more than 200-fold. In addition, marked decreases in albumin and iron concentrations were observed. These results show that SAA, CRP, and haptoglobin are positive acute-phase proteins, whereas albumin and iron are negative acute-phase reactants in rhesus macaques.

KW - Faculty of Health and Medical Sciences

KW - Primates

KW - Inflammation

KW - Acute phase proteins

KW - Veterinary medicine

U2 - 10.1638/2013-0153R.1

DO - 10.1638/2013-0153R.1

M3 - Journal article

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ER -

Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)

Abstract

Keywords

UN SDGs

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