Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)

TY - JOUR

T1 - Acute-phase responses in healthy and diseased rhesus macaques (Macaca mulatta)

AU - Krogh, Anne Kirstine Havnsøe

AU - Lundsgaard, Jo F. H.

AU - Bakker, Jaco

AU - Langermans, Jan A. M.

AU - Verreck, Frank A. W.

AU - Kjelgaard-Hansen, Mads

AU - Jacobsen, Stine

AU - Bertelsen, Mads Frost

PY - 2014/6

Y1 - 2014/6

N2 - Five acute-phase reactants-serum amyloid A (SAA), C-reactive protein (CRP), haptoglobin, albumin, and iron-were measured using commercially available assays in 110 healthy rhesus macaques (Macaca mulatta), and reference intervals were established for future use in health monitoring of this species. Reference intervals established were as follows: SAA, 29.5-87.7 mg/L; CRP, 0-17.5 mg/L; haptoglobin, 354.3-2,414.7 mg/L; albumin, 36.1-53.0 g/L; and iron, 13.3-40.2 μmol/L. Furthermore, changes in the acute-phase reactants were studied in two additional groups of animals: eight rhesus macaques suffering from acute traumatic injuries and nine rhesus macaques experimentally infected with Mycobacterium tuberculosis reflecting a chronic active inflammation. In animals with inflammation, SAA and haptoglobin concentrations were moderately increased, while CRP increased more than 200-fold. In addition, marked decreases in albumin and iron concentrations were observed. These results show that SAA, CRP, and haptoglobin are positive acute-phase proteins, whereas albumin and iron are negative acute-phase reactants in rhesus macaques.

AB - Five acute-phase reactants-serum amyloid A (SAA), C-reactive protein (CRP), haptoglobin, albumin, and iron-were measured using commercially available assays in 110 healthy rhesus macaques (Macaca mulatta), and reference intervals were established for future use in health monitoring of this species. Reference intervals established were as follows: SAA, 29.5-87.7 mg/L; CRP, 0-17.5 mg/L; haptoglobin, 354.3-2,414.7 mg/L; albumin, 36.1-53.0 g/L; and iron, 13.3-40.2 μmol/L. Furthermore, changes in the acute-phase reactants were studied in two additional groups of animals: eight rhesus macaques suffering from acute traumatic injuries and nine rhesus macaques experimentally infected with Mycobacterium tuberculosis reflecting a chronic active inflammation. In animals with inflammation, SAA and haptoglobin concentrations were moderately increased, while CRP increased more than 200-fold. In addition, marked decreases in albumin and iron concentrations were observed. These results show that SAA, CRP, and haptoglobin are positive acute-phase proteins, whereas albumin and iron are negative acute-phase reactants in rhesus macaques.

KW - Faculty of Health and Medical Sciences

KW - Primates

KW - Inflammation

KW - Acute phase proteins

KW - Veterinary medicine

U2 - 10.1638/2013-0153R.1

DO - 10.1638/2013-0153R.1

M3 - Journal article

C2 - 25000691

SN - 1042-7260

VL - 45

SP - 306

EP - 314

JO - Journal of Zoo and Wildlife Medicine

JF - Journal of Zoo and Wildlife Medicine

IS - 2

ER -