Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels

Daniel Bloch Hansen; Zu-Cheng Ye; Kirstine Calloe; Thomas Hartig Braunstein; Johannes Pauli Hofgaard; Bruce R Ransom; Morten Schak Nielsen; Nanna MacAulay

doi:10.1074/jbc.M114.582155

Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels

Daniel Bloch Hansen, Zu-Cheng Ye, Kirstine Calloe, Thomas Hartig Braunstein, Johannes Pauli Hofgaard, Bruce R Ransom, Morten Schak Nielsen, Nanna MacAulay

34 Citations (Scopus)

Abstract

Background: The permeability and physiological role of several large pore (hemi)channels are unresolved.

Results: Large pore (hemi)channels, when heterologously expressed, display isoform-specific permeability and gating for ions and fluorescent dyes.

Significance: Although large pore channels have characteristic properties in overexpression systems, these properties may be undetectable in native cells.

Conclusion: Large pore channels have isoform-specific transport characteristics that can be used for their identification.

Original language	English
Journal	The Journal of Biological Chemistry
Volume	289
Issue number	38
Pages (from-to)	26058-73
Number of pages	16
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M114.582155
Publication status	Published - 19 Sept 2014

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title = "Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels",

abstract = "Background: The permeability and physiological role of several large pore (hemi)channels are unresolved.Results: Large pore (hemi)channels, when heterologously expressed, display isoform-specific permeability and gating for ions and fluorescent dyes.Significance: Although large pore channels have characteristic properties in overexpression systems, these properties may be undetectable in native cells.Conclusion: Large pore channels have isoform-specific transport characteristics that can be used for their identification.",

author = "Hansen, {Daniel Bloch} and Zu-Cheng Ye and Kirstine Calloe and Braunstein, {Thomas Hartig} and Hofgaard, {Johannes Pauli} and Ransom, {Bruce R} and Nielsen, {Morten Schak} and Nanna MacAulay",

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T1 - Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels

AU - Hansen, Daniel Bloch

AU - Ye, Zu-Cheng

AU - Calloe, Kirstine

AU - Braunstein, Thomas Hartig

AU - Hofgaard, Johannes Pauli

AU - Ransom, Bruce R

AU - Nielsen, Morten Schak

AU - MacAulay, Nanna

PY - 2014/9/19

Y1 - 2014/9/19

N2 - Background: The permeability and physiological role of several large pore (hemi)channels are unresolved.Results: Large pore (hemi)channels, when heterologously expressed, display isoform-specific permeability and gating for ions and fluorescent dyes.Significance: Although large pore channels have characteristic properties in overexpression systems, these properties may be undetectable in native cells.Conclusion: Large pore channels have isoform-specific transport characteristics that can be used for their identification.

AB - Background: The permeability and physiological role of several large pore (hemi)channels are unresolved.Results: Large pore (hemi)channels, when heterologously expressed, display isoform-specific permeability and gating for ions and fluorescent dyes.Significance: Although large pore channels have characteristic properties in overexpression systems, these properties may be undetectable in native cells.Conclusion: Large pore channels have isoform-specific transport characteristics that can be used for their identification.

U2 - 10.1074/jbc.M114.582155

DO - 10.1074/jbc.M114.582155

M3 - Journal article

C2 - 25086040

SN - 0021-9258

VL - 289

SP - 26058

EP - 26073

JO - The Journal of Biological Chemistry

JF - The Journal of Biological Chemistry

IS - 38

ER -

Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels

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