Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels

TY - JOUR

T1 - Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels

AU - Hansen, Daniel Bloch

AU - Ye, Zu-Cheng

AU - Calloe, Kirstine

AU - Braunstein, Thomas Hartig

AU - Hofgaard, Johannes Pauli

AU - Ransom, Bruce R

AU - Nielsen, Morten Schak

AU - MacAulay, Nanna

N1 - © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

PY - 2014/9/19

Y1 - 2014/9/19

N2 - Background: The permeability and physiological role of several large pore (hemi)channels are unresolved.Results: Large pore (hemi)channels, when heterologously expressed, display isoform-specific permeability and gating for ions and fluorescent dyes.Significance: Although large pore channels have characteristic properties in overexpression systems, these properties may be undetectable in native cells.Conclusion: Large pore channels have isoform-specific transport characteristics that can be used for their identification.

AB - Background: The permeability and physiological role of several large pore (hemi)channels are unresolved.Results: Large pore (hemi)channels, when heterologously expressed, display isoform-specific permeability and gating for ions and fluorescent dyes.Significance: Although large pore channels have characteristic properties in overexpression systems, these properties may be undetectable in native cells.Conclusion: Large pore channels have isoform-specific transport characteristics that can be used for their identification.

U2 - 10.1074/jbc.M114.582155

DO - 10.1074/jbc.M114.582155

M3 - Journal article

C2 - 25086040

SN - 0021-9258

VL - 289

SP - 26058

EP - 26073

JO - The Journal of Biological Chemistry

JF - The Journal of Biological Chemistry

IS - 38

ER -