Activation of interfacial enzymes at membrane surfaces

Ole G. Mouritsen; Thomas L. Andresen; Avi Halperin; Per Lyngs Hansen; Ask F. Jakobsen; Uffe Bernchou Jensen; Morten Jensen; Kent Jørgensen; Thomas Kaasgaard; Chad Leidy; Adam Cohen Simonsen; Günther H. Peters; Matthias Weiss

doi:10.1088/0953-8984/18/28/S12

Activation of interfacial enzymes at membrane surfaces

Ole G. Mouritsen^*, Thomas L. Andresen, Avi Halperin, Per Lyngs Hansen, Ask F. Jakobsen, Uffe Bernchou Jensen, Morten Jensen, Kent Jørgensen, Thomas Kaasgaard, Chad Leidy, Adam Cohen Simonsen, Günther H. Peters, Matthias Weiss

^*Corresponding author for this work

64 Citations (Scopus)

Abstract

A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A₂ (sPLA₂), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA₂ as derived from a range of different experimental and theoretical investigations.

Original language	English
Article number	S12
Journal	Journal of Physics Condensed Matter
Volume	18
Issue number	28
Pages (from-to)	S1293-S1304
ISSN	0953-8984
DOIs	https://doi.org/10.1088/0953-8984/18/28/S12
Publication status	Published - 19 Jul 2006

Access to Document

10.1088/0953-8984/18/28/S12

Cite this

Mouritsen, O. G., Andresen, T. L., Halperin, A., Hansen, P. L., Jakobsen, A. F., Jensen, U. B., Jensen, M., Jørgensen, K., Kaasgaard, T., Leidy, C., Simonsen, A. C., Peters, G. H., & Weiss, M. (2006). Activation of interfacial enzymes at membrane surfaces. Journal of Physics Condensed Matter, 18(28), S1293-S1304. Article S12. https://doi.org/10.1088/0953-8984/18/28/S12

@article{4446c1a912ed486c84359e0e74523d43,

title = "Activation of interfacial enzymes at membrane surfaces",

abstract = "A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (sPLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA2 as derived from a range of different experimental and theoretical investigations.",

author = "Mouritsen, {Ole G.} and Andresen, {Thomas L.} and Avi Halperin and Hansen, {Per Lyngs} and Jakobsen, {Ask F.} and Jensen, {Uffe Bernchou} and Morten Jensen and Kent J{\o}rgensen and Thomas Kaasgaard and Chad Leidy and Simonsen, {Adam Cohen} and Peters, {G{\"u}nther H.} and Matthias Weiss",

year = "2006",

month = jul,

day = "19",

doi = "10.1088/0953-8984/18/28/S12",

language = "English",

volume = "18",

pages = "S1293--S1304",

journal = "Journal of Physics Condensed Matter",

issn = "0953-8984",

publisher = "Institute of Physics Publishing Ltd",

number = "28",

}

TY - JOUR

T1 - Activation of interfacial enzymes at membrane surfaces

AU - Mouritsen, Ole G.

AU - Andresen, Thomas L.

AU - Halperin, Avi

AU - Hansen, Per Lyngs

AU - Jakobsen, Ask F.

AU - Jensen, Uffe Bernchou

AU - Jensen, Morten

AU - Jørgensen, Kent

AU - Kaasgaard, Thomas

AU - Leidy, Chad

AU - Simonsen, Adam Cohen

AU - Peters, Günther H.

AU - Weiss, Matthias

PY - 2006/7/19

Y1 - 2006/7/19

N2 - A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (sPLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA2 as derived from a range of different experimental and theoretical investigations.

AB - A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (sPLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA2 as derived from a range of different experimental and theoretical investigations.

UR - http://www.scopus.com/inward/record.url?scp=33745625415&partnerID=8YFLogxK

U2 - 10.1088/0953-8984/18/28/S12

DO - 10.1088/0953-8984/18/28/S12

M3 - Journal article

AN - SCOPUS:33745625415

SN - 0953-8984

VL - 18

SP - S1293-S1304

JO - Journal of Physics Condensed Matter

JF - Journal of Physics Condensed Matter

IS - 28

M1 - S12

ER -

Activation of interfacial enzymes at membrane surfaces

Abstract

Access to Document

Other files and links

Fingerprint

Cite this