Activation of interfacial enzymes at membrane surfaces

Ole G. Mouritsen; Thomas L. Andresen; Avi Halperin; Per Lyngs Hansen; Ask F. Jakobsen; Uffe Bernchou Jensen; Morten Jensen; Kent Jørgensen; Thomas Kaasgaard; Chad Leidy; Adam Cohen Simonsen; Günther H. Peters; Matthias Weiss

doi:10.1088/0953-8984/18/28/S12

Activation of interfacial enzymes at membrane surfaces

Ole G. Mouritsen^*, Thomas L. Andresen, Avi Halperin, Per Lyngs Hansen, Ask F. Jakobsen, Uffe Bernchou Jensen, Morten Jensen, Kent Jørgensen, Thomas Kaasgaard, Chad Leidy, Adam Cohen Simonsen, Günther H. Peters, Matthias Weiss

^*Corresponding author af dette arbejde

64 Citationer (Scopus)

Abstract

A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A₂ (sPLA₂), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA₂ as derived from a range of different experimental and theoretical investigations.

Originalsprog	Engelsk
Artikelnummer	S12
Tidsskrift	Journal of Physics Condensed Matter
Vol/bind	18
Udgave nummer	28
Sider (fra-til)	S1293-S1304
ISSN	0953-8984
DOI	https://doi.org/10.1088/0953-8984/18/28/S12
Status	Udgivet - 19 jul. 2006

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Mouritsen, O. G., Andresen, T. L., Halperin, A., Hansen, P. L., Jakobsen, A. F., Jensen, U. B., Jensen, M., Jørgensen, K., Kaasgaard, T., Leidy, C., Simonsen, A. C., Peters, G. H., & Weiss, M. (2006). Activation of interfacial enzymes at membrane surfaces. Journal of Physics Condensed Matter, 18(28), S1293-S1304. Artikel S12. https://doi.org/10.1088/0953-8984/18/28/S12

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abstract = "A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (sPLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA2 as derived from a range of different experimental and theoretical investigations.",

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AU - Mouritsen, Ole G.

AU - Andresen, Thomas L.

AU - Halperin, Avi

AU - Hansen, Per Lyngs

AU - Jakobsen, Ask F.

AU - Jensen, Uffe Bernchou

AU - Jensen, Morten

AU - Jørgensen, Kent

AU - Kaasgaard, Thomas

AU - Leidy, Chad

AU - Simonsen, Adam Cohen

AU - Peters, Günther H.

AU - Weiss, Matthias

PY - 2006/7/19

Y1 - 2006/7/19

N2 - A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (sPLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA2 as derived from a range of different experimental and theoretical investigations.

AB - A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (sPLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given of our current understanding of the physical mechanisms responsible for activation of sPLA2 as derived from a range of different experimental and theoretical investigations.

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U2 - 10.1088/0953-8984/18/28/S12

DO - 10.1088/0953-8984/18/28/S12

M3 - Journal article

AN - SCOPUS:33745625415

SN - 0953-8984

VL - 18

SP - S1293-S1304

JO - Journal of Physics Condensed Matter

JF - Journal of Physics Condensed Matter

IS - 28

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Activation of interfacial enzymes at membrane surfaces

Abstract

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