Acetylation regulates WRN catalytic activities and affects base excision DNA repair

TY - JOUR

T1 - Acetylation regulates WRN catalytic activities and affects base excision DNA repair

AU - Muftuoglu, Meltem

AU - Kusumoto, Rika

AU - Speina, Elzbieta

AU - Beck, Gad

AU - Cheng, Wen-Hsing

AU - Bohr, Vilhelm A

PY - 2008/1

Y1 - 2008/1

N2 - The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.

AB - The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.

KW - Aging

KW - Catalysis

KW - Cell Line

KW - DNA

KW - DNA Damage

KW - DNA Repair

KW - Exodeoxyribonucleases

KW - Exonucleases

KW - Hela Cells

KW - Histone Acetyltransferases

KW - Humans

KW - Protein Processing, Post-Translational

KW - Protein Structure, Tertiary

KW - RecQ Helicases

KW - Recombinant Proteins

KW - Transcription, Genetic

U2 - 10.1371/journal.pone.0001918

DO - 10.1371/journal.pone.0001918

M3 - Journal article

C2 - 18398454

SN - 1932-6203

VL - 3

SP - e1918

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 4

ER -