A transparent nanowire-based cell impalement device suitable for detailed cell-nanowire interaction studies

Florian Mumm; Kai M. Beckwith; Sara Bonde; Karen Laurence Martinez; Pawel Sikorski

doi:10.1002/smll.201201314

A transparent nanowire-based cell impalement device suitable for detailed cell-nanowire interaction studies

Florian Mumm, Kai M. Beckwith, Sara Bonde, Karen Laurence Martinez, Pawel Sikorski

Department of Chemistry

48 Citations (Scopus)

Abstract

A method to fabricate inexpensive and transparent nanowire impalement devices is invented based on CuO nanowire arrays grown by thermal oxidation. By employing a novel process the nanowires are transferred to a transparent, cell-compatible epoxy membrane. Cargo delivery and detailed cell-nanowire interaction studies are performed, revealing that the cell plasma membrane tightly wraps the nanowires, while cell membrane penetration is not observed. The presented device offers an efficient investigation platform for further optimization, leading towards a simple and versatile impalement delivery system.

Original language	English
Journal	Small
Volume	9
Issue number	2
Pages (from-to)	263-272
Number of pages	10
ISSN	1613-6810
DOIs	https://doi.org/10.1002/smll.201201314
Publication status	Published - 28 Jan 2013

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10.1002/smll.201201314

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abstract = "A method to fabricate inexpensive and transparent nanowire impalement devices is invented based on CuO nanowire arrays grown by thermal oxidation. By employing a novel process the nanowires are transferred to a transparent, cell-compatible epoxy membrane. Cargo delivery and detailed cell-nanowire interaction studies are performed, revealing that the cell plasma membrane tightly wraps the nanowires, while cell membrane penetration is not observed. The presented device offers an efficient investigation platform for further optimization, leading towards a simple and versatile impalement delivery system.",

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AU - Mumm, Florian

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AU - Sikorski, Pawel

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AB - A method to fabricate inexpensive and transparent nanowire impalement devices is invented based on CuO nanowire arrays grown by thermal oxidation. By employing a novel process the nanowires are transferred to a transparent, cell-compatible epoxy membrane. Cargo delivery and detailed cell-nanowire interaction studies are performed, revealing that the cell plasma membrane tightly wraps the nanowires, while cell membrane penetration is not observed. The presented device offers an efficient investigation platform for further optimization, leading towards a simple and versatile impalement delivery system.

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DO - 10.1002/smll.201201314

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A transparent nanowire-based cell impalement device suitable for detailed cell-nanowire interaction studies

Abstract

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