A transparent nanowire-based cell impalement device suitable for detailed cell-nanowire interaction studies

TY - JOUR

T1 - A transparent nanowire-based cell impalement device suitable for detailed cell-nanowire interaction studies

AU - Mumm, Florian

AU - Beckwith, Kai M.

AU - Bonde, Sara

AU - Martinez, Karen Laurence

AU - Sikorski, Pawel

PY - 2013/1/28

Y1 - 2013/1/28

N2 - A method to fabricate inexpensive and transparent nanowire impalement devices is invented based on CuO nanowire arrays grown by thermal oxidation. By employing a novel process the nanowires are transferred to a transparent, cell-compatible epoxy membrane. Cargo delivery and detailed cell-nanowire interaction studies are performed, revealing that the cell plasma membrane tightly wraps the nanowires, while cell membrane penetration is not observed. The presented device offers an efficient investigation platform for further optimization, leading towards a simple and versatile impalement delivery system.

AB - A method to fabricate inexpensive and transparent nanowire impalement devices is invented based on CuO nanowire arrays grown by thermal oxidation. By employing a novel process the nanowires are transferred to a transparent, cell-compatible epoxy membrane. Cargo delivery and detailed cell-nanowire interaction studies are performed, revealing that the cell plasma membrane tightly wraps the nanowires, while cell membrane penetration is not observed. The presented device offers an efficient investigation platform for further optimization, leading towards a simple and versatile impalement delivery system.

U2 - 10.1002/smll.201201314

DO - 10.1002/smll.201201314

M3 - Journal article

C2 - 23034997

SN - 1613-6810

VL - 9

SP - 263

EP - 272

JO - Small

JF - Small

IS - 2

ER -