A tale of ligands big and small: An update on how pentameric ligand-gated ion channels interact with agonists and proteins

TY - JOUR

T1 - A tale of ligands big and small

T2 - An update on how pentameric ligand-gated ion channels interact with agonists and proteins

AU - Pless, Stephan A.

AU - Sivilotti, Lucia G.

N1 - Corrigendum to ‘A tale of ligands big and small an update on how pentameric ligand-gated ion channels interact with agonists and proteins’, [Curr Opin Physiol 2 (2018) 19–26](S2468867317300354) 10.1016/j.cophys.2018.07.005

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Pentameric ligand-gated ion channels (pLGICs, also known as Cys-loop receptors) are a large family of ion channels expressed in all Bilateria and in several groups of bacteria and archaea. They are activated by small-molecule neurotransmitters to mediate fast neurotransmission at many central and peripheral synapses and are the target of several drugs and insecticides. Here we review recent advances in the field, focussing on new insights on the structure of the agonist-binding site and on newly discovered protein–protein interactions involving pLGICs.

AB - Pentameric ligand-gated ion channels (pLGICs, also known as Cys-loop receptors) are a large family of ion channels expressed in all Bilateria and in several groups of bacteria and archaea. They are activated by small-molecule neurotransmitters to mediate fast neurotransmission at many central and peripheral synapses and are the target of several drugs and insecticides. Here we review recent advances in the field, focussing on new insights on the structure of the agonist-binding site and on newly discovered protein–protein interactions involving pLGICs.

U2 - 10.1016/j.cophys.2017.12.012

DO - 10.1016/j.cophys.2017.12.012

M3 - Review

C2 - 31231710

AN - SCOPUS:85051048195

SN - 2468-8681

VL - 2

SP - 19

EP - 26

JO - Current Opinion in Physiology

JF - Current Opinion in Physiology

ER -