Abstract
PURPOSE: A systematic review was performed to find evidence for prophylactic administration of antibiotics in relation to treatment of maxillofacial fractures.
METHODS: Four studies were retrieved that fulfilled most of the requirements of being randomized controlled clinical trials.
RESULTS: An analysis of these studies showed a 3-fold decrease in the infection rate of mandibular fractures in the antibiotic treated groups compared with the control groups. A variety of antibiotics had been used with an apparently uniform effect. A "1-shot" regimen or a 1-day treatment course had a similar or perhaps even better effect than 7 days of treatment. No infections were related to condylar, maxillary, or zygoma fractures.
CONCLUSION: A 1-shot or 1-day administration of prophylactic antibiotics seem to be the best documented to reduce infections in the management of mandibular fractures not involving the condylar region.
| Original language | English |
|---|---|
| Journal | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons |
| Volume | 64 |
| Issue number | 11 |
| Pages (from-to) | 1664-8 |
| Number of pages | 5 |
| ISSN | 0278-2391 |
| DOIs | |
| Publication status | Published - Nov 2006 |
Keywords
- Antibiotic Prophylaxis/statistics & numerical data
- Humans
- Mandibular Fractures/surgery
- Maxillary Fractures/surgery
- Randomized Controlled Trials as Topic
- Surgical Wound Infection/prevention & control
- Zygomatic Fractures/surgery