A systematic review of prophylactic antibiotics in the surgical treatment of maxillofacial fractures

TY - JOUR

T1 - A systematic review of prophylactic antibiotics in the surgical treatment of maxillofacial fractures

AU - Andreasen, Jens O

AU - Jensen, Simon S

AU - Schwartz, Ole

AU - Hillerup, Yören

PY - 2006/11

Y1 - 2006/11

N2 - PURPOSE: A systematic review was performed to find evidence for prophylactic administration of antibiotics in relation to treatment of maxillofacial fractures.METHODS: Four studies were retrieved that fulfilled most of the requirements of being randomized controlled clinical trials.RESULTS: An analysis of these studies showed a 3-fold decrease in the infection rate of mandibular fractures in the antibiotic treated groups compared with the control groups. A variety of antibiotics had been used with an apparently uniform effect. A "1-shot" regimen or a 1-day treatment course had a similar or perhaps even better effect than 7 days of treatment. No infections were related to condylar, maxillary, or zygoma fractures.CONCLUSION: A 1-shot or 1-day administration of prophylactic antibiotics seem to be the best documented to reduce infections in the management of mandibular fractures not involving the condylar region.

AB - PURPOSE: A systematic review was performed to find evidence for prophylactic administration of antibiotics in relation to treatment of maxillofacial fractures.METHODS: Four studies were retrieved that fulfilled most of the requirements of being randomized controlled clinical trials.RESULTS: An analysis of these studies showed a 3-fold decrease in the infection rate of mandibular fractures in the antibiotic treated groups compared with the control groups. A variety of antibiotics had been used with an apparently uniform effect. A "1-shot" regimen or a 1-day treatment course had a similar or perhaps even better effect than 7 days of treatment. No infections were related to condylar, maxillary, or zygoma fractures.CONCLUSION: A 1-shot or 1-day administration of prophylactic antibiotics seem to be the best documented to reduce infections in the management of mandibular fractures not involving the condylar region.

KW - Antibiotic Prophylaxis/statistics & numerical data

KW - Humans

KW - Mandibular Fractures/surgery

KW - Maxillary Fractures/surgery

KW - Randomized Controlled Trials as Topic

KW - Surgical Wound Infection/prevention & control

KW - Zygomatic Fractures/surgery

U2 - 10.1016/j.joms.2006.02.032

DO - 10.1016/j.joms.2006.02.032

M3 - Review

C2 - 17052593

SN - 0278-2391

VL - 64

SP - 1664

EP - 1668

JO - Journal of Oral and Maxillofacial Surgery

JF - Journal of Oral and Maxillofacial Surgery

IS - 11

ER -