A systematic review of peri-operative melatonin

L P H Andersen; M U Werner; J Rosenberg; I Gögenur

doi:10.1111/anae.12717

A systematic review of peri-operative melatonin

L P H Andersen, M U Werner, J Rosenberg, I Gögenur

Department of Clinical Medicine

45 Citations (Scopus)

Abstract

We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I(2) 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.

Original language	English
Journal	Anaesthesia
Volume	69
Issue number	10
Pages (from-to)	1163-1171
Number of pages	9
ISSN	0003-2409
DOIs	https://doi.org/10.1111/anae.12717
Publication status	Published - 2014

Keywords

Anxiety
Humans
Melatonin
Pain, Postoperative
Perioperative Care
Randomized Controlled Trials as Topic
Sleep

Access to Document

10.1111/anae.12717

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/anae.12717

Cite this

@article{53d63476d763418c9633be954026e396,

title = "A systematic review of peri-operative melatonin",

abstract = "We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I(2) 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.",

keywords = "Anxiety, Humans, Melatonin, Pain, Postoperative, Perioperative Care, Randomized Controlled Trials as Topic, Sleep",

author = "Andersen, {L P H} and Werner, {M U} and J Rosenberg and I G{\"o}genur",

note = "{\textcopyright} 2014 The Association of Anaesthetists of Great Britain and Ireland.",

year = "2014",

doi = "10.1111/anae.12717",

language = "English",

volume = "69",

pages = "1163--1171",

journal = "Anaesthesia",

issn = "0003-2409",

publisher = "Wiley-Blackwell",

number = "10",

}

TY - JOUR

T1 - A systematic review of peri-operative melatonin

AU - Andersen, L P H

AU - Werner, M U

AU - Rosenberg, J

AU - Gögenur, I

PY - 2014

Y1 - 2014

N2 - We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I(2) 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.

AB - We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I(2) 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.

KW - Anxiety

KW - Humans

KW - Melatonin

KW - Pain, Postoperative

KW - Perioperative Care

KW - Randomized Controlled Trials as Topic

KW - Sleep

U2 - 10.1111/anae.12717

DO - 10.1111/anae.12717

M3 - Review

C2 - 24835540

SN - 0003-2409

VL - 69

SP - 1163

EP - 1171

JO - Anaesthesia

JF - Anaesthesia

IS - 10

ER -

A systematic review of peri-operative melatonin

Abstract

Keywords

Access to Document

Fingerprint

Cite this