A systematic review of peri-operative melatonin

L P H Andersen; M U Werner; J Rosenberg; I Gögenur

doi:10.1111/anae.12717

A systematic review of peri-operative melatonin

L P H Andersen, M U Werner, J Rosenberg, I Gögenur

Institut for Klinisk Medicin

45 Citationer (Scopus)

Abstract

We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I(2) 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.

Originalsprog	Engelsk
Tidsskrift	Anaesthesia
Vol/bind	69
Udgave nummer	10
Sider (fra-til)	1163-1171
Antal sider	9
ISSN	0003-2409
DOI	https://doi.org/10.1111/anae.12717
Status	Udgivet - 2014

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10.1111/anae.12717

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/anae.12717

Citationsformater

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AU - Rosenberg, J

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AB - We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with placebo, melatonin reduced the standardised mean difference (95% CI) pre-operative anxiety score by 0.88 (0.44-1.33) and postoperative pain score by 1.06 (0.23-1.88). The magnitude of effect was unreliable due to substantial statistical heterogeneity, with I(2) 87% and 94%, respectively. Qualitative reviews suggested the melatonin improved sleep quality and emergence behaviour, and might be capable of reducing oxidative stress and anaesthetic requirements.

KW - Anxiety

KW - Humans

KW - Melatonin

KW - Pain, Postoperative

KW - Perioperative Care

KW - Randomized Controlled Trials as Topic

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A systematic review of peri-operative melatonin

Abstract

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